Evidence map›Paper›PMID 34067324›Full record

ArticleMethods and protocols2021

Conformational Control of DNA Origami by DNA Oligomers, Intercalators and UV Light.

Ruixin Li, Haorong Chen, Hyeongwoon Lee, Jong Hyun Choi

Abstract read
In one paragraph

Article in Methods and protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. pH-Driven Actuation of Unmodified DNA Origami Rectangles.Angewandte Chemie (International ed. in English) · 2026
    Article
  2. A nanoscale Jitterbug transformer from DNA.Nature communications · 2026
    Article
  3. Article
  4. Radiation and DNA Origami Nanotechnology: Probing Structural Integrity at the Nanoscale.Chemphyschem : a European journal of chemical physics and physical chemistry · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ruixin LiSchool of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-9079-1138
Haorong ChenSchool of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Hyeongwoon LeeSchool of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Jong Hyun ChoiSchool of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-0507-3052

Funding

National Science Foundation 1710344U.S. Department of Energy DE-SC0020673
6 · The paper itself

Abstract

DNA origami has garnered great attention due to its excellent programmability and precision. It offers a powerful means to create complex nanostructures which may not be possible by other methods. The macromolecular structures may be used as static templates for arranging proteins and other molecules. They are also capable of undergoing structural transformation in response to external signals, which may be exploited for sensing and actuation at the nanoscale. Such on-demand reconfigurations are executed mostly by DNA oligomers through base-pairing and/or strand displacement, demonstrating drastic shape changes between two different states, for example, open and close. Recent studies have developed new mechanisms to modulate the origami conformation in a controllable, progressive manner. Here we present several methods for conformational control of DNA origami nanostructures including chemical adducts and UV light as well as widely applied DNA oligomers. The detailed methods should be useful for beginners in the field of DNA nanotechnology.

Indexed as

conformationDNA origamiintercalatorstrand displacementstressUV

Identifiers

PMID34067324
PMCPMC8163164

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.