Evidence map›Paper›PMID 34067300›Full record

ArticleBiology2021

Use of Antibiotics and Probiotics Reduces the Risk of Metachronous Gastric Cancer after Endoscopic Resection.

Junya Arai, Ryota Niikura, Yoku Hayakawa, Takuya Kawahara, Tetsuro Honda, Kenkei Hasatani, Naohiro Yoshida, Tsutomu Nishida, Tetsuya Sumiyoshi, Shu Kiyotoki and 7 more

Open access · goldAbstract read
In one paragraph

Article in Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. ATR-CHK1 Axis Inhibitors in Gastric Cancer Treatment.International journal of molecular sciences · 2025
    Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. International journal of biological sciences · 2024
    Article
  8. Article
  9. Non-Gastro hep advances · 2023
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 11 institutions in 1 country.

Junya AraiDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.ORCID 0000-0002-4905-7046
Ryota NiikuraDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.ORCID 0000-0001-5047-6195
Yoku HayakawaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.ORCID 0000-0002-3988-2499
Takuya KawaharaClinical Research Promotion Center, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
Tetsuro HondaDepartment of Gastroenterology, Nagasaki Harbor Medical Center, Nagasaki-shi, Nagasaki 850-8555, Japan.
Kenkei HasataniDepartment of Gastroenterology, Fukui Prefectural Hospital, Fukui-shi, Fukui 910-0846, Japan.
Naohiro YoshidaDepartment of Gastroenterology, Ishikawa Prefectural Central Hospital, Kanazawa-shi, Ishikawa 920-8530, Japan.
Tsutomu NishidaDepartment of Gastroenterology, Toyonaka Municipal Hospital, Toyonaka-shi, Osaka 560-8565, Japan.ORCID 0000-0003-4037-9003
Tetsuya SumiyoshiDepartment of Gastroenterology, Tonan Hospital, Sapporo-shi, Hokkaido 060-0004, Japan.
Shu KiyotokiDepartment of Gastroenterology, Shuto General Hospital, Yanai-shi, Yamaguchi 333-0801, Japan.
Takashi IkeyaDepartment of Gastroenterology, St. Luke's International Hospital, Chuo-ku, Tokyo 104-8560, Japan.
Masahiro AraiDepartment of Gastroenterology, Nerima Hikarigaoka Hospital, Nerima-ku, Tokyo 179-0072, Japan.
Nobumi SuzukiDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Yosuke TsujiDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Atsuo YamadaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Takashi KawaiDepartment of Gastroenterological Endoscopy, Tokyo Medical University, Shinjuku-ku, Tokyo 160-0023, Japan.
Kazuhiko KoikeDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
The University of Tokyo · JPTokyo Medical University · JPFukui Prefectural Hospital · JPIshikawa Prefectural Central Hospital · JPNagasaki Medical Center · JPNerima General Hospital · JPShuto General Hospital · JPSt. Luke's International Hospital · JPTonan Hospital · JPToyonaka Municipal Hospital · JPUniversity of Tokyo Hospital · JP

Funding

KAKENHI 20K08375 (R. Niikura) and 17H05081 (Y. Hayakawa)
6 · The paper itself

Abstract

Metachronous gastric cancer often occurs after endoscopic resection. Appropriate management, including chemoprevention, is required after the procedure. This study was performed to evaluate the association between medication use and the incidence of metachronous gastric cancer after endoscopic resection. This multicenter retrospective cohort study was conducted with data from nine hospital databases on patients who underwent endoscopic resection for gastric cancer between 2014 and 2019. The primary outcome was the incidence of metachronous gastric cancer. We evaluated the associations of metachronous gastric cancer occurrence with medication use and clinical factors. Hazard ratios were adjusted by age and Charlson comorbidity index scores, with and without consideration of sex, smoking status, and receipt of

Indexed as

antibioticsendoscopic resectiongut microbiomemetachronous gastric cancerprobiotics

Identifiers

PMID34067300
PMCPMC8224738
OpenAlexW3164695771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.