Evidence map›Paper›PMID 34067258›Full record

ArticleInternational journal of molecular sciences2021

Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective Study.

Shuhei Fukunaga, Dan Nakano, Takumi Kawaguchi, Mohammed Eslam, Akihiro Ouchi, Tsutomu Nagata, Hidefumi Kuroki, Hidemichi Kawata, Hirohiko Abe, Ryuichi Nouno and 4 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Review
  3. [Metabolic-associated fatty liver disease (MAFLD): a multisystemic disease beyond the liver].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
    Review
  4. Article
  5. Article
  6. MAFLD: from a disease framework to patient care.Hepatology international · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. MAFLD: a multisystem disease.Therapeutic advances in endocrinology and metabolism · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Shuhei FukunagaDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.ORCID 0000-0002-2715-7564
Dan NakanoDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
Takumi KawaguchiDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.ORCID 0000-0002-7064-4325
Mohammed EslamStorr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, 176 Hawkesbury Rd, Westmead, NSW 2145, Australia.
Akihiro OuchiDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
Tsutomu NagataDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
Hidefumi KurokiDiagnostic Imaging Center, Kurume University Hospital, 67 Asahi-machi, Kurume 830-0011, Japan.
Hidemichi KawataDiagnostic Imaging Center, Kurume University Hospital, 67 Asahi-machi, Kurume 830-0011, Japan.
Hirohiko AbeDepartment of Gastroenterology, Kumamoto Central Hospital, 2921 Haramizu, Kikuyo, Kikuchi 869-1102, Japan.
Ryuichi NounoDepartment of Gastroenterology, Kumamoto Central Hospital, 2921 Haramizu, Kikuyo, Kikuchi 869-1102, Japan.
Koutaro KawaguchiKurate Hospital, 2425-9 Nakayama Kurate-machi, Kurate 807-1312, Japan.
Jacob GeorgeStorr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, 176 Hawkesbury Rd, Westmead, NSW 2145, Australia.
Keiichi MitsuyamaDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
Takuji TorimuraDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
Kurume University · JPKumamoto Chuo Hospital · JPKurume University Hospital · JPThe University of Sydney · AU

Funding

Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research (C) JP20K08395
6 · The paper itself

Abstract

Colorectal adenoma is linked to metabolic dysfunction. Metabolic dysfunction-associated fatty liver disease (MAFLD) has a precise definition and three subtypes, including non-obese MAFLD. We aimed to investigate the impact of MAFLD on the prevalence of colorectal adenoma by comparing it to non-alcoholic fatty liver disease (NAFLD) in health check-up examinees. This is a multicenter retrospective study. We enrolled 124 consecutive health check-up examinees who underwent colonoscopy. NAFLD and MAFLD were present in 58 and 63 examinees, respectively. Colorectal adenoma was diagnosed by biopsy. The impact of the MAFLD definition on the prevalence of colorectal adenoma was investigated by logistic regression, decision-tree, and random forest analyses. In logistic regression analysis, MAFLD was identified as the only independent factor associated with the presence of colorectal adenoma (OR 3.191; 95% CI 1.494-7.070;

Indexed as

AdenomaAdultAgedAged, 80 and overColonoscopyColorectal NeoplasmsFemaleHumansMaleMiddle AgedNon-alcoholic Fatty Liver DiseasePrevalenceRetrospective StudiesRisk Factorscolorectal neoplasmsliver steatosismetabolic syndromenon-alcoholic fatty liver diseasethinness

Identifiers

PMID34067258
PMCPMC8196881
OpenAlexW3165273733

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.