Evidence map›Paper›PMID 34067090›Full record

ReviewJournal of personalized medicine2021

The Equitable Implementation of Cystic Fibrosis Personalized Medicines in Canada.

Genevieve Shemie, Minh Thu Nguyen, John Wallenburg, Felix Ratjen, Bartha Maria Knoppers

Abstract readReview
In one paragraph

Review in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Genevieve ShemieCentre of Genomics and Medicine, Department of Human Genetics, Faculty of Medicine, McGill University, Montreal, QC H3A 0C7, Canada.ORCID 0000-0002-0007-0194
Minh Thu NguyenCentre of Genomics and Medicine, Department of Human Genetics, Faculty of Medicine, McGill University, Montreal, QC H3A 0C7, Canada.
John WallenburgCystic Fibrosis Canada, Toronto, ON M4P 2C9, Canada.ORCID 0000-0003-0256-0741
Felix RatjenDepartment of Pediatrics Translational Medicine, Division of Respiratory Medicine, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada.
Bartha Maria KnoppersCentre of Genomics and Medicine, Department of Human Genetics, Faculty of Medicine, McGill University, Montreal, QC H3A 0C7, Canada.

Funding

Genome Canada OGI-148
6 · The paper itself

Abstract

This article identifies the potential sources of inequity in three stages of integrating cystic fibrosis personalized medicines into the Canadian healthcare system and proposes mitigating strategies: (1) clinical research and diagnostic testing; (2) regulatory oversight and market authorization; and (3) implementation into the healthcare system. There is concern that differential access will cast a dark shadow over personalized medicine by stratifying the care that groups of patients will receive-not only based on their genetic profiles, but also on the basis of their socioeconomic status. Furthermore, there is a need to re-evaluate regulatory and market approval mechanisms to accommodate the unique nature of personalized medicines. Physical and financial accessibility ought to be remedied before personalized medicines can be equitably delivered to patients. This article identifies the socio-ethical and legal challenges at each stage and recommends mitigating policy solutions.

Indexed as

accessCanadacystic fibrosisethicshealthcare equityhealth policypersonalized medicines

Identifiers

PMID34067090
PMCPMC8151662

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.