ArticleCurrent issues in molecular biology2021
Anti-Inflammatory Effect of Pineapple Rhizome Bromelain through Downregulation of the NF-κB- and MAPKs-Signaling Pathways in Lipopolysaccharide (LPS)-Stimulated RAW264.7 Cells.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Current issues in molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Exploring the Therapeutic Potential of Bromelain: Applications, Benefits, and Mechanisms.Nutrients · 2024Pooled it
- Investigating theResearch in pharmaceutical sciences · 2026Article
- Evaluation of the Potential Anti-Inflammatory Effect of a New Coumarin-Quinoline Hybrid in LPS-Induced Neuroinflammation.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Potential health benefits of bromelain: a critical review of the current literature.Frontiers in nutrition · 2026Review
- Correction: Insuan et al. Anti-Inflammatory Effect of Pineapple Rhizome Bromelain through Downregulation of the NF-κB- and MAPKs-Signaling Pathways in Lipopolysaccharide (LPS)-Stimulated RAW264.7 Cells.Current issues in molecular biology · 2025Article
- Evaluation of anti-inflammatory and neuroprotective effect of walnut shell pectin.Scientific reports · 2025Article
- Protective role of bromelain's antioxidant and anti-inflammatory effects in experimental lower limb ischemia-reperfusion injury.Scientific reports · 2025Article
- Enhancing Muscle Strength and Reducing Inflammation: The Combined Effects of Hydrolyzed House Cricket Protein Supplementation and Concurrent Training in Older Women.Food science & nutrition · 2025Article
- Bromelain Protects Against PTZ-Induced Glial Damage and Inflammation: An In Vitro and In Silico Study.Cell biochemistry and biophysics · 2025Article
- Bromelain in Obesity Therapy: A Review of Anti-Inflammatory and Metabolic Mechanisms.International journal of molecular sciences · 2025Review
- Synbiotic pineapple beverage increases life span in Caenorhabditis elegans, ameliorates cognitive impairment, and restores gut microbiome diversity in D-galactose-induced aged C57BL/6 mice.Biogerontology · 2025Article
- Bromelain Supplementation in the Management of Otitis Media with Effusion in Children.Children (Basel, Switzerland) · 2024Article
- The Effect of Diosmin, Escin, and Bromelain on Human Endothelial Cells Derived from the Umbilical Vein and the Varicose Vein-A Preliminary Study.Biomedicines · 2023Article
- The Activation of Nrf2/HO-1 by 8-Epi-7-deoxyloganic Acid Attenuates Inflammatory Symptoms through the Suppression of the MAPK/NF-κB Signaling Cascade in In Vitro and In Vivo Models.Antioxidants (Basel, Switzerland) · 2022Article
- Bromelain Protects Critically Perfused Musculocutaneous Flap Tissue from Necrosis.Biomedicines · 2022Article
- Ex-vivo mucolytic and anti-inflammatory activity of BromAc in tracheal aspirates from COVID-19.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022Article
- Resveratrol Downregulates Granulocyte-Macrophage Colony-Stimulating Factor-Induced Oncostatin M Production through Blocking of PI3K/Akt/NF-κB Signal Cascade in Neutrophil-like Differentiated HL-60 Cells.Current issues in molecular biology · 2022Article
- Beneficial Properties of Bromelain.Nutrients · 2021Review
- Bromelain Extract Exerts Antiarthritic Effects via Chondroprotection and the Suppression of TNF-α-Induced NF-κB and MAPK Signaling.Plants (Basel, Switzerland) · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 3 institutions in 1 country.
Orapin InsuanDepartment of Medical Technology, School of Allied Health Sciences, University of Phayao, Phayao 56000, Thailand.
Phornphimon JanchaiNanotechnology and Biotechnology Research Division, Kasetsart Agricultural and Agro-Industrial Product Improvement Institute (KAPI), Kasetsart University, Bangkok 10900, Thailand.
Benchaluk ThongchuaiDepartment of Medical Technology, School of Allied Health Sciences, University of Phayao, Phayao 56000, Thailand.
Rujirek ChaiwongsaDepartment of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Supaporn KhamchunDepartment of Medical Technology, School of Allied Health Sciences, University of Phayao, Phayao 56000, Thailand.
Somphot SaoinDepartment of Medical Technology, School of Allied Health Sciences, University of Phayao, Phayao 56000, Thailand.ORCID 0000-0002-7502-7000
Wimonrut InsuanDepartment of Veterinary Technology, Faculty of Veterinary Technology, Kasetsart University, Bangkok 10900, Thailand.
Peraphan PothacharoenDepartment of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Waraporn ApiwatanapiwatNanotechnology and Biotechnology Research Division, Kasetsart Agricultural and Agro-Industrial Product Improvement Institute (KAPI), Kasetsart University, Bangkok 10900, Thailand.
Antika BoondaengNanotechnology and Biotechnology Research Division, Kasetsart Agricultural and Agro-Industrial Product Improvement Institute (KAPI), Kasetsart University, Bangkok 10900, Thailand.
Pilanee VaithanomsatNanotechnology and Biotechnology Research Division, Kasetsart Agricultural and Agro-Industrial Product Improvement Institute (KAPI), Kasetsart University, Bangkok 10900, Thailand.ORCID 0000-0003-4280-2426
Kasetsart University · THUniversity of Phayao · THChiang Mai University · TH
Funding
National Research Council of Thailand BEDO-NRCT 70/2562
Abstract
Bromelain is a mixture of proteolytic enzymes derived from pineapple (
Indexed as
AnanasAnimalsAnti-Inflammatory AgentsBromelainsDown-RegulationLipopolysaccharidesMacrophagesMAP Kinase Signaling SystemMiceNF-kappa BRAW 264.7 CellsRhizomeSignal TransductionAnti-Inflammatory AgentsBromelainsLipopolysaccharidesNF-kappa BbromelaininflammationMAPKsNF-κBpro-inflammatory cytokines
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.