Evidence map›Paper›PMID 34067060›Full record

ArticleInternational journal of molecular sciences2021

miR-200c-3p Regulates Epitelial-to-Mesenchymal Transition in Epicardial Mesothelial Cells by Targeting Epicardial Follistatin-Related Protein 1.

Elena Pontemezzo, Eleonora Foglio, Enza Vernucci, Alessandra Magenta, Marco D'Agostino, Sara Sileno, Elena Astanina, Federico Bussolino, Laura Pellegrini, Antonia Germani and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Epicardium-myocardium crosstalk orchestrates heart development.Frontiers in cell and developmental biology · 2025
    Review
  4. Review
  5. Epicardial EMT and cardiac repair: an update.Stem cell research & therapy · 2024
    Review
  6. miRNAs in Heart Development and Disease.International journal of molecular sciences · 2024
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Elena PontemezzoDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Eleonora FoglioDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Enza VernucciDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Alessandra MagentaExperimental Immunology Laboratory, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Via dei Monti di Creta 104, 00167 Rome, Italy.ORCID 0000-0002-9054-337X
Marco D'AgostinoExperimental Immunology Laboratory, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Via dei Monti di Creta 104, 00167 Rome, Italy.ORCID 0000-0002-7682-6357
Sara SilenoExperimental Immunology Laboratory, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Via dei Monti di Creta 104, 00167 Rome, Italy.
Elena AstaninaDepartment of Oncology, University of Turin, 10060 Candiolo, Italy.
Federico BussolinoDepartment of Oncology, University of Turin, 10060 Candiolo, Italy.
Laura PellegriniDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-8833-2987
Antonia GermaniExperimental Immunology Laboratory, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Via dei Monti di Creta 104, 00167 Rome, Italy.
Matteo Antonio RussoIRCCS San Raffaele Pisana and MEBIC Consortium, 00166 Rome, Italy.ORCID 0000-0002-5847-6015
Federica LimanaDepartment of Human Science and Promotion of the Quality of Life, San Raffaele Roma Open University, 00166 Rome, Italy.
Istituto Dermopatico dell'Immacolata · ITSapienza University of Rome · ITCandiolo Cancer Institute · ITIRCCS Ospedale San Raffaele · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

Fondazione RomaMinistero dell'Istruzione, dell'Università e della Ricerca
6 · The paper itself

Abstract

Recent findings suggest that epithelial to mesenchymal transition (EMT), a key step during heart development, is involved in cardiac tissue repair following myocardial infarction (MI). MicroRNAs (miRNAs) act as key regulators in EMT processes; however, the mechanisms by which miRNAs target epicardial EMT remain largely unknown. Here, by using an

Indexed as

Epithelial-Mesenchymal TransitionAnimalsBiomarkersEpitheliumFemaleFollistatin-Related ProteinsMesodermMiceMice, Inbred C57BLMicroRNAsNeoplastic Stem CellsPericardiumTransforming Growth Factor beta1BiomarkersFollistatin-Related ProteinsFstl1 protein, mouseMicroRNAsMirn200 microRNA, mouseTransforming Growth Factor beta1EMCsepicardial EMTFSTL1miR200cmolecular rehabilitation

Identifiers

PMID34067060
PMCPMC8125323
OpenAlexW3159710756

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.