Evidence map›Paper›PMID 34067039›Full record

ArticleJournal of clinical medicine2021

Clinical Relevance of Corticosteroid Withdrawal on Graft Histological Lesions in Low-Immunological-Risk Kidney Transplant Patients.

Domingo Hernández, Juana Alonso-Titos, Teresa Vázquez, Myriam León, Abelardo Caballero, María Angeles Cobo, Eugenia Sola, Verónica López, Pedro Ruiz-Esteban, Josep María Cruzado and 12 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02284464 (Steroid Withdrawal and Novo Donor-specific Anti-HLA Antibodies in Renal Transplant Patients), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02284464 phase4completednot on this map

Steroid Withdrawal and Novo Donor-specific Anti-HLA Antibodies in Renal Transplant Patients: a Prospective, Randomized and Controlled Study in Parallel Groups

TypeinterventionalSponsorFundación Pública Andaluza para la Investigación de Málaga en Biomedicina y SaludRan2015 to 2019Enrolled230ConditionsOther Complication of Kidney Transplant, Renal Transplant RejectionArmsPrednisone withdrawal, Prednisone continuation
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Steroid avoidance or withdrawal for kidney transplant recipients.The Cochrane database of systematic reviews · 2026
    Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 5 institutions in 1 country.

Domingo HernándezNephrology Department, Hospital Regional Universitario de Málaga, University of Málaga, IBIMA, REDinREN (RD16/0009/0006), E-29010 Málaga, Spain.
Juana Alonso-TitosNephrology Department, Hospital Regional Universitario de Málaga, University of Málaga, IBIMA, REDinREN (RD16/0009/0006), E-29010 Málaga, Spain.
Teresa VázquezNephrology Department, Hospital Regional Universitario de Málaga, University of Málaga, IBIMA, REDinREN (RD16/0009/0006), E-29010 Málaga, Spain.
Myriam LeónPathology Department, Hospital Regional Universitario de Malaga, IBIMA, REDinREN (RD16/0009/0006), E-29010 Málaga, Spain.
Abelardo CaballeroImmunology Department, Hospital Regional Universitario de Málaga, University of Málaga, IBIMA, REDinREN (RD16/0009/0006), E-29010 Málaga, Spain.
María Angeles CoboNephrology Department, Hospital Universitario de Canarias, Instituto de Tecnologías Biomédicas-Universidad La Laguna, REDinREN (RD16/0009/0031), E-38320 Tenerife, Spain.
Eugenia SolaNephrology Department, Hospital Regional Universitario de Málaga, University of Málaga, IBIMA, REDinREN (RD16/0009/0006), E-29010 Málaga, Spain.
Verónica LópezNephrology Department, Hospital Regional Universitario de Málaga, University of Málaga, IBIMA, REDinREN (RD16/0009/0006), E-29010 Málaga, Spain.ORCID 0000-0002-1793-7065
Pedro Ruiz-EstebanNephrology Department, Hospital Regional Universitario de Málaga, University of Málaga, IBIMA, REDinREN (RD16/0009/0006), E-29010 Málaga, Spain.
Josep María CruzadoNephrology Department, Hospital Universitari de Bellvitge, University of Barcelona, IDIBELL, REDinREN (RD16/0009/0003), E-08907 Barcelona, Spain.
Joana SellarésNephrology Department, Hospital Universitari Valld'Hebron, Universitat Autonoma, Barcelona, REDinREN (RD16/0009/0030), E-08035 Barcelona, Spain.
Francesc MoresoNephrology Department, Hospital Universitari Valld'Hebron, Universitat Autonoma, Barcelona, REDinREN (RD16/0009/0030), E-08035 Barcelona, Spain.ORCID 0000-0002-7267-3963
Anna ManonellesNephrology Department, Hospital Universitari de Bellvitge, University of Barcelona, IDIBELL, REDinREN (RD16/0009/0003), E-08907 Barcelona, Spain.ORCID 0000-0003-2456-388X
Alberto ToríoImmunology Department, Hospital Regional Universitario de Málaga, University of Málaga, IBIMA, REDinREN (RD16/0009/0006), E-29010 Málaga, Spain.
Mercedes CabelloNephrology Department, Hospital Regional Universitario de Málaga, University of Málaga, IBIMA, REDinREN (RD16/0009/0006), E-29010 Málaga, Spain.
Juan Delgado-BurgosNephrology Department, Hospital Regional Universitario de Málaga, University of Málaga, IBIMA, REDinREN (RD16/0009/0006), E-29010 Málaga, Spain.
Cristina CasasNephrology Department, Hospital Regional Universitario de Málaga, University of Málaga, IBIMA, REDinREN (RD16/0009/0006), E-29010 Málaga, Spain.
Elena GutiérrezNephrology Department, Hospital Regional Universitario de Málaga, University of Málaga, IBIMA, REDinREN (RD16/0009/0006), E-29010 Málaga, Spain.
Cristina JirondaNephrology Department, Hospital Regional Universitario de Málaga, University of Málaga, IBIMA, REDinREN (RD16/0009/0006), E-29010 Málaga, Spain.
Julia KanterNephrology Department, Hospital Universitario Dr. Peset, E-46017 Valencia, Spain.
Daniel SerónNephrology Department, Hospital Universitari Valld'Hebron, Universitat Autonoma, Barcelona, REDinREN (RD16/0009/0030), E-08035 Barcelona, Spain.ORCID 0000-0003-2054-653X
Armando TorresNephrology Department, Hospital Universitario de Canarias, Instituto de Tecnologías Biomédicas-Universidad La Laguna, REDinREN (RD16/0009/0031), E-38320 Tenerife, Spain.
Hospital Regional Universitario de Málaga · ESUniversitat Autònoma de Barcelona · ESBellvitge University Hospital · ESHospital Universitario de Canarias · ESHospital Universitario Doctor Peset · ES

Funding

Instituto de Salud Carlos III ICI14/0016Instituto de Salud Carlos III PI17/02043Instituto de Salud Carlos III RD16/0009/0003Instituto de Salud Carlos III RD16/0009/0006Instituto de Salud Carlos III RD16/0009/0030Instituto de Salud Carlos III RD16/0009/0031
6 · The paper itself

Abstract

The impact of corticosteroid withdrawal on medium-term graft histological changes in kidney transplant (KT) recipients under standard immunosuppression is uncertain. As part of an open-label, multicenter, prospective, phase IV, 24-month clinical trial (ClinicalTrials.gov, NCT02284464) in low-immunological-risk KT recipients, 105 patients were randomized, after a protocol-biopsy at 3 months, to corticosteroid continuation (CSC,

Indexed as

borderline lesionschronic graft histological changescorticosteroids withdrawalkidney transplantlow immunological riskprotocol biopsyrejectionsubclinical inflammation

Identifiers

PMID34067039
PMCPMC8125434
OpenAlexW3157465604

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.