Evidence map›Paper›PMID 34067034›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Chest X-ray Bone Suppression for Improving Classification of Tuberculosis-Consistent Findings.

Sivaramakrishnan Rajaraman, Ghada Zamzmi, Les Folio, Philip Alderson, Sameer Antani

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. GAN-based bone suppression using a combined loss function.Frontiers in artificial intelligence · 2026
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  8. Semantically redundant training data removal and deep model classification performance: A study with chest X-rays.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Sivaramakrishnan RajaramanNational Library of Medicine, National Institutes of Health, Bethesda, MD 20814, USA.ORCID 0000-0003-0871-8634
Ghada ZamzmiNational Library of Medicine, National Institutes of Health, Bethesda, MD 20814, USA.
Les FolioClinical Center, Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD 20814, USA.
Philip AldersonSchool of Medicine, Saint Louis University, St. Louis, MO 63103, USA.ORCID 0000-0003-3617-7433
Sameer AntaniNational Library of Medicine, National Institutes of Health, Bethesda, MD 20814, USA.ORCID 0000-0002-0040-1387
National Institutes of Health · USNational Institutes of Health Clinical Center · USSaint Louis University · US

Funding

Machine learning and artificial intelligence research for clinical medical image processingZIALM010018 · NLM · NATIONAL LIBRARY OF MEDICINE · PI ANTANI, SAMEER · 2021 to 2025
$9.0M
6 · The paper itself

Abstract

Chest X-rays (CXRs) are the most commonly performed diagnostic examination to detect cardiopulmonary abnormalities. However, the presence of bony structures such as ribs and clavicles can obscure subtle abnormalities, resulting in diagnostic errors. This study aims to build a deep learning (DL)-based bone suppression model that identifies and removes these occluding bony structures in frontal CXRs to assist in reducing errors in radiological interpretation, including DL workflows, related to detecting manifestations consistent with tuberculosis (TB). Several bone suppression models with various deep architectures are trained and optimized using the proposed combined loss function and their performances are evaluated in a cross-institutional test setting using several metrics such as mean absolute error (MAE), peak signal-to-noise ratio (PSNR), structural similarity index measure (SSIM), and multiscale structural similarity measure (MS-SSIM). The best-performing model (ResNet-BS) (PSNR = 34.0678; MS-SSIM = 0.9828) is used to suppress bones in the publicly available Shenzhen and Montgomery TB CXR collections. A VGG-16 model is pretrained on a large collection of publicly available CXRs. The CXR-pretrained model is then fine-tuned individually on the non-bone-suppressed and bone-suppressed CXRs of Shenzhen and Montgomery TB CXR collections to classify them as showing normal lungs or TB manifestations. The performances of these models are compared using several performance metrics such as accuracy, the area under the curve (AUC), sensitivity, specificity, precision, F-score, and Matthews correlation coefficient (MCC), analyzed for statistical significance, and their predictions are qualitatively interpreted through class-selective relevance maps (CRMs). It is observed that the models trained on bone-suppressed CXRs (Shenzhen: AUC = 0.9535 ± 0.0186; Montgomery: AUC = 0.9635 ± 0.0106) significantly outperformed (

Indexed as

bone suppressionchest X-raysclassificationconvolutional neural networksdeep learninginterpretationstatistical analysistuberculosis

Identifiers

PMID34067034
PMCPMC8151767
OpenAlexW3159693056

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.