Evidence map›Paper›PMID 34067022›Full record

ArticleCancers2021

The PI3K/mTOR Pathway Is Targeted by Rare Germline Variants in Patients with Both Melanoma and Renal Cell Carcinoma.

Jean-Noël Hubert, Voreak Suybeng, Maxime Vallée, Tiffany M Delhomme, Eve Maubec, Anne Boland, Delphine Bacq, Jean-François Deleuze, Fanélie Jouenne, Paul Brennan and 4 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Decoding the mechanisms behind second primary cancers.Journal of translational medicine · 2025
    Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Jean-Noël HubertSection of Genetics, International Agency for Research on Cancer (IARC-WHO), 69372 Lyon, France.
Voreak SuybengGustave Roussy, Département de Biopathologie, 94805 Villejuif, France.
Maxime ValléeSection of Genetics, International Agency for Research on Cancer (IARC-WHO), 69372 Lyon, France.
Tiffany M DelhommeSection of Genetics, International Agency for Research on Cancer (IARC-WHO), 69372 Lyon, France.ORCID 0000-0003-0265-4246
Eve MaubecDepartment of Dermatology, AP-HP, Hôpital Avicenne, University Paris 13, 93000 Bobigny, France.ORCID 0000-0003-1658-6686
Anne BolandCentre National de Recherche en Génomique Humaine, Université Paris-Saclay, CEA, 91057 Evry, France.ORCID 0000-0001-8789-5676
Delphine BacqCentre National de Recherche en Génomique Humaine, Université Paris-Saclay, CEA, 91057 Evry, France.
Jean-François DeleuzeCentre National de Recherche en Génomique Humaine, Université Paris-Saclay, CEA, 91057 Evry, France.
Fanélie JouenneGustave Roussy, Département de Biopathologie, 94805 Villejuif, France.ORCID 0000-0002-6706-7424
Paul BrennanSection of Genetics, International Agency for Research on Cancer (IARC-WHO), 69372 Lyon, France.
James D McKaySection of Genetics, International Agency for Research on Cancer (IARC-WHO), 69372 Lyon, France.
Marie-Françoise AvrilAssociation Robert Debré pour la Recherche Médicale, 75006 Paris, France.
Brigitte Bressac-de PailleretsGustave Roussy, Département de Biopathologie, 94805 Villejuif, France.ORCID 0000-0003-0245-8608
Estelle ChanudetSection of Genetics, International Agency for Research on Cancer (IARC-WHO), 69372 Lyon, France.
Centre international de recherche sur le cancer · FRCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRInstitut Gustave Roussy · FRAssociation Robert Debré · FRDélégation Paris 5 · FRInserm · FR

Funding

World Health Organization 001
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

genetic susceptibilitymelanomarare variants enrichmentrenal cell carcinomaWES

Identifiers

PMID34067022
PMCPMC8125037
OpenAlexW3158668979

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.