Evidence map›Paper›PMID 34066992›Full record

ReviewDermatopathology (Basel, Switzerland)2021

Ichthyoses-A Clinical and Pathological Spectrum from Heterogeneous Cornification Disorders to Inflammation.

Dieter Metze, Heiko Traupe, Kira Süßmuth

Open access · goldAbstract readReview
In one paragraph

Review in Dermatopathology (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. New Insights in Paediatric Dermatopathology-2nd Edition.Dermatopathology (Basel, Switzerland) · 2024
    Article
  6. Article
  7. Advanced Anterior Eye Segment Imaging for Ichthyosis.Journal of clinical medicine · 2023
    Article
  8. Review
  9. Article
  10. New Insights in Paediatric Dermatopathology.Dermatopathology (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Dieter MetzeKlinik für Hautkrankheiten, Universitätsklinik Münster, 48149 Münster, Germany.
Heiko TraupeKlinik für Hautkrankheiten, Universitätsklinik Münster, 48149 Münster, Germany.
Kira SüßmuthKlinik für Hautkrankheiten, Universitätsklinik Münster, 48149 Münster, Germany.
Klinik und Poliklinik für Hautkrankheiten · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ichthyoses are inborn keratinization disorders affecting the skin only (non-syndromic) or are associated with diseases of internal organs (syndromic). In newborns, they can be life-threatening. The identification of the gene defects resulted in reclassification and a better understanding of the pathophysiology. Histopathologic patterns include orthohyperkeratosis with a reduced or well-developed stratum granulosum, hyperkeratosis with ortho- and parakeratosis with preserved or prominent stratum granulosum, and epidermolytic ichthyosis. Another pattern features "perinuclear vacuoles and binucleated keratinocytes", which is associated with keratin mutations. Some ichthyoses are histologically defined by psoriasis-like features, and distinct subtypes show follicular hyperkeratosis. In addition to histological and immunohistochemical methods, these patterns allow a better histopathologic diagnosis.

Indexed as

dermatopathologyhereditary keratinization disordersichthyosisimmunohistochemistrypattern analysis

Identifiers

PMID34066992
PMCPMC8161842
OpenAlexW3158766159

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.