Evidence map›Paper›PMID 34066955›Full record

ArticleInternational journal of molecular sciences2021

PGRP-LB: An Inside View into the Mechanism of the Amidase Reaction.

Julien Orlans, Carole Vincent-Monegat, Isabelle Rahioui, Catherine Sivignon, Agata Butryn, Laurent Soulère, Anna Zaidman-Remy, Allen M Orville, Abdelaziz Heddi, Pierre Aller and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  4. Article
  5. The Role of AaPGRP-LB in the Immune Response ofInternational journal of molecular sciences · 2025
    Article
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  7. Article
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  11. Pharmacological Effect of Caffeine onArchives of Razi Institute · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Julien OrlansUniv Lyon, INSA Lyon, INRAE, BF2I, UMR 203, 69621 Villeurbanne, France.ORCID 0000-0002-6933-2287
Carole Vincent-MonegatUniv Lyon, INSA Lyon, INRAE, BF2I, UMR 203, 69621 Villeurbanne, France.ORCID 0000-0001-6377-5573
Isabelle RahiouiUniv Lyon, INSA Lyon, INRAE, BF2I, UMR 203, 69621 Villeurbanne, France.
Catherine SivignonUniv Lyon, INSA Lyon, INRAE, BF2I, UMR 203, 69621 Villeurbanne, France.
Agata ButrynDiamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, UK.ORCID 0000-0002-5227-4770
Laurent SoulèreUniv Lyon, INSA Lyon, Université Claude Bernard Lyon 1, CPE Lyon, UMR 5246, CNRS, ICBMS, Institut de Chimie et de Biochimie Moléculaires et Supramoléculaires, Bât. E. Lederer, 1 rue Victor Grignard, 69622 Villeurbanne, France.ORCID 0000-0002-0488-550X
Anna Zaidman-RemyUniv Lyon, INSA Lyon, INRAE, BF2I, UMR 203, 69621 Villeurbanne, France.ORCID 0000-0003-2550-1752
Allen M OrvilleDiamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, UK.
Abdelaziz HeddiUniv Lyon, INSA Lyon, INRAE, BF2I, UMR 203, 69621 Villeurbanne, France.
Pierre AllerDiamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, UK.
Pedro Da SilvaUniv Lyon, INSA Lyon, INRAE, BF2I, UMR 203, 69621 Villeurbanne, France.
Université Claude Bernard Lyon 1 · FRRutherford Appleton Laboratory · GB

Funding

Institut National des Sciences Appliquées de Lyon ANR-17-CE20-0031-01
6 · The paper itself

Abstract

Peptidoglycan recognition proteins (PGRPs) are ubiquitous among animals and play pivotal functions in insect immunity. Non-catalytic PGRPs are involved in the activation of immune pathways by binding to the peptidoglycan (PGN), whereas amidase PGRPs are capable of cleaving the PGN into non-immunogenic compounds.

Indexed as

AmidohydrolasesAmino Acid SequenceAnimalsCarrier ProteinsDrosophila melanogasterModels, MolecularMutant ProteinsPeptidoglycanProtein IsoformsProtein Structure, SecondarySugarsVirulence Factors, BordetellaZincamidaseAmidohydrolasesCarrier ProteinsMutant ProteinsPeptidoglycanpeptidoglycan recognition proteinProtein IsoformsSugarstracheal cytotoxin, Bordetella pertussisVirulence Factors, BordetellaZincDrosophila melanogasterinnate immunitypeptidoglycan recognition proteinPGRP-LBX-ray crystallography

Identifiers

PMID34066955
PMCPMC8124813
OpenAlexW3157407411

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.