ReviewPharmaceutics2021
Continuous Twin Screw Granulation: A Review of Recent Progress and Opportunities in Formulation and Equipment Design.
Review in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 44 citations in OpenAlex.
- A Material-Process-Equipment Integrated Design Method for Accelerating the Process Development of Twin-Screw Wet Granulation.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Control Strategy Considerations for the Continuous Manufacturing of Low-dose Oral Solid Dosage Formulations.The AAPS journal · 2026Review
- Process characterisation of continuous ring layer wet granulation at small scale.International journal of pharmaceutics: X · 2025Article
- An Advanced Twin-Screw Granulation Technology: The use of Non-Volatile Solvents with High Solubilizing Capacity.AAPS PharmSciTech · 2024Article
- Evaluation of Polyvinyl Alcohol as Binder during Continuous Twin Screw Wet Granulation.Pharmaceutics · 2024Article
- Process Simulation of Twin-Screw Granulation: A Review.Pharmaceutics · 2024Review
- Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation-Where Are We Now?AAPS PharmSciTech · 2024Review
- Integrated Continuous Wet Granulation and Drying: Process Evaluation and Comparison with Batch Processing.Pharmaceutics · 2023Article
- Application of I-Optimal Design for Modeling and Optimizing the Operational Parameters of Ibuprofen Granules in Continuous Twin-Screw Wet Granulation.Biomedicines · 2023Article
- Pharmaceutical Application of Process Understanding and Optimization Techniques: A Review on the Continuous Twin-Screw Wet Granulation.Biomedicines · 2023Review
- Towards the Continuous Manufacturing of Liquisolid Tablets Containing Simethicone and Loperamide Hydrochloride with the Use of a Twin-Screw Granulator.Pharmaceutics · 2023Article
- Advances in Twin-Screw Granulation.Pharmaceutics · 2021Article
- Review: Continuous Manufacturing of Small Molecule Solid Oral Dosage Forms.Pharmaceutics · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Continuous twin screw wet granulation is one of the key continuous manufacturing technologies that have gained significant interest in the pharmaceutical industry as well as in academia over the last ten years. Given its considerable advantages compared to wet granulation techniques operated in batch mode such as high shear granulation and fluid bed granulation, several equipment manufacturers have designed their own manufacturing setup. This has led to a steep increase in the research output in this field. However, most studies still focused on a single (often placebo) formulation, hence making it difficult to assess the general validity of the obtained results. Therefore, current review provides an overview of recent progress in the field of continuous twin screw wet granulation, with special focus on the importance of the formulation aspect and raw material properties. It gives practical guidance for novel and more experienced users of this technique and highlights some of the unmet needs that require further research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.