Evidence map›Paper›PMID 34066920›Full record

ArticleInternational journal of molecular sciences2021

IgM and IgG Immunoreactivity of SARS-CoV-2 Recombinant M Protein.

Zorana Lopandić, Isidora Protić-Rosić, Aleksandra Todorović, Sofija Glamočlija, Marija Gnjatović, Danica Ćujic, Marija Gavrović-Jankulović

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

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  13. Evaluation of S- and M-Proteins Expressed inPathogens (Basel, Switzerland) · 2022
    Article
  14. A six-month study of anti-SARS-CoV-2 BNT162b2 mRNA vaccination: A comparative analysis of essential trace elements and anti-RBD IgG sera levels.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zorana LopandićDepartment of Biochemistry, Faculty of Chemistry, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-8034-4086
Isidora Protić-RosićDepartment of Biochemistry, Faculty of Chemistry, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-1536-9770
Aleksandra TodorovićInstitute for the Application of Nuclear Energy, University of Belgrade, 11000 Beograde, Serbia.
Sofija GlamočlijaInstitute for the Application of Nuclear Energy, University of Belgrade, 11000 Beograde, Serbia.ORCID 0000-0003-0497-5852
Marija GnjatovićInstitute for the Application of Nuclear Energy, University of Belgrade, 11000 Beograde, Serbia.
Danica ĆujicInstitute for the Application of Nuclear Energy, University of Belgrade, 11000 Beograde, Serbia.
Marija Gavrović-JankulovićDepartment of Biochemistry, Faculty of Chemistry, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-8591-4391
University of Belgrade · RS

Funding

Ministry of Education and Technological Development, Republic of Serbia 451-03-9/2021-14/200168, 451-03-68/2020-14/200019
6 · The paper itself

Abstract

Diagnostic evaluation of specific antibodies against the SARS-CoV-2 virus is mainly based on spike (S) and nucleocapsid (N) proteins. Despite the critical functions in virus infection and contribution to the pattern of immunodominance in COVID-19, exploitation of the most abundant membrane (M) protein in the SARS-CoV-2 serology tests is minimal. This study investigated the recombinant M protein's immunoreactivity with the sera from COVID-19 convalescents. In silico designed protein was created from the outer N-terminal part (19 aa) and internal C-terminal tail (101-222 aa) of the M protein (YP_009724393.1) and was recombinantly produced and purified. The designed M protein (16,498.74 Da, p

Indexed as

Coronavirus M ProteinsCOVID-19HumansImmunoglobulin GImmunoglobulin MRecombinant ProteinsSARS-CoV-2Sensitivity and SpecificityViral Matrix ProteinsCoronavirus M ProteinsImmunoglobulin GImmunoglobulin Mmembrane protein, SARS-CoV-2Recombinant ProteinsViral Matrix ProteinsantigenicityCOVID-19ELISAIgG reactivityIgM reactivitySARS-CoV-2 membrane protein

Identifiers

PMID34066920
PMCPMC8125631
OpenAlexW3158688463

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.