ArticleNutrients2021
High and Low Haemoglobin Levels in Early Pregnancy Are Associated to a Higher Risk of Miscarriage: A Population-Based Cohort Study.
Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 25 citations in OpenAlex.
- Right-sizing Incentives.Journal of development economics · 2026Article
- Making Bricks from Straw: Resources and Productivity in Health Care.The American economic review · 2026Article
- Observational
- Association between iron deficiency and fertility.Acta obstetricia et gynecologica Scandinavica · 2025Observational
- How much could anemia-related interventions reduce the HIV disparity in adverse birth outcomes?American journal of epidemiology · 2025Article
- Novel proteomics biomarkers of recurrent pregnancy loss reflect the dysregulation of immune interactions at the maternal-fetal interface.Frontiers in immunology · 2025Article
- Risk and protective factors of miscarriage: Evidence from a nationally representative sample of women in India.Journal of family medicine and primary care · 2024Article
- Maternal anaemia during early pregnancy and the risk of neonatal outcomes: a prospective cohort study in Central China.BMJ paediatrics open · 2024Article
- Prevalence and determinants of anaemia among pregnant women in a high malaria transmission setting: a cross-sectional study in rural Burkina Faso.The Pan African medical journal · 2024Article
- Article
- The global burden of maternal disorders attributable to iron deficiency related sub-disorders in 204 countries and territories: an analysis for the Global Burden of Disease study.Frontiers in public health · 2024Article
- Effect of Adherence to the Mediterranean Diet on Maternal Iron Related Biochemical Parameters during Pregnancy and Gestational Weight Gain.Life (Basel, Switzerland) · 2023Article
- Anaemia among Pregnant Women Visiting Obstetric Department of a Tertiary Care Centre: A Descriptive Cross-sectional Study.JNMA; journal of the Nepal Medical Association · 2023Article
- Establishing pregnancy-specific haematological reference intervals in Ghana; a three-center cross-sectional study.PloS one · 2023Article
- Maternal Serum Zinc, Copper, Magnesium, and Iron in Spontaneous Abortions.Indian journal of clinical biochemistry : IJCB · 2023Article
- Adapting prenatal iron supplementation to maternal needs results in optimal child neurodevelopment: a follow-up of the ECLIPSES Study.BMC pregnancy and childbirth · 2022Article
- Article
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4 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
To evaluate whether women with anaemia or high haemoglobin (Hb) in early pregnancy would be at higher risk of miscarriage, this population-based cohort study involved 9453 women whose pregnancies were monitored at primary care centres between 2007 and 2012. The computerised clinical histories were used to collect: Hb measurements (up to 14 weeks of gestation), miscarriage before or by 24 weeks of gestation, and other maternal characteristics. The relation between anaemia (Hb < 110 g/L), normal Hb (110-140 g/L, reference), and high Hb concentrations (≥140 g/L) with miscarriage were expressed as adjusted OR with 95%CI. Restricted cubic spline models were applied to evaluate the dose-response relationships. A total of 520 (5.5%) women were recorded as having a miscarriage. The rate of miscarriage in anaemia, normal Hb, and high Hb concentrations was 8.4%, 5.1%, and 10.2%, respectively. Compared with women with normal Hb at the first trimester, the multivariable-adjusted OR for miscarriage was 2.11 (95%CI, 1.38-3.21) for women with anaemia and 1.83 (95%CI, 1.29-2.58) for women with high Hb. Hb concentrations showed a U-shaped association with miscarriage, with the lowest incidence among women with Hb of 120-130 g/L. These data highlight the importance of considering anaemia and high Hb levels in early pregnancy as harmful indicators for miscarriage.
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