Evidence map›Paper›PMID 34066857›Full record

ArticleCancers2021

Prediction of Human Papillomavirus (HPV) Association of Oropharyngeal Cancer (OPC) Using Radiomics: The Impact of the Variation of CT Scanner.

Reza Reiazi, Colin Arrowsmith, Mattea Welch, Farnoosh Abbas-Aghababazadeh, Christopher Eeles, Tony Tadic, Andrew J Hope, Scott V Bratman, Benjamin Haibe-Kains

Abstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
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  5. Review
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  9. Article
  10. Review
  11. [Research progress in CT-based radiomics constructing hypopharyngeal cancer and multisystem tumor prediction model].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Reza ReiaziRadiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2CI, Canada.
Colin ArrowsmithRadiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2CI, Canada.
Mattea WelchRadiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2CI, Canada.
Farnoosh Abbas-AghababazadehRadiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2CI, Canada.ORCID 0000-0001-6427-9379
Christopher EelesRadiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2CI, Canada.
Tony TadicRadiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2CI, Canada.
Andrew J HopeRadiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2CI, Canada.
Scott V BratmanRadiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2CI, Canada.ORCID 0000-0001-8610-4908
Benjamin Haibe-KainsRadiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2CI, Canada.

Funding

CIHR 426366
6 · The paper itself

Abstract

Studies have shown that radiomic features are sensitive to the variability of imaging parameters (e.g., scanner models), and one of the major challenges in these studies lies in improving the robustness of quantitative features against the variations in imaging datasets from multi-center studies. Here, we assess the impact of scanner choice on computed tomography (CT)-derived radiomic features to predict the association of oropharyngeal squamous cell carcinoma with human papillomavirus (HPV). This experiment was performed on CT image datasets acquired from two different scanner manufacturers. We demonstrate strong scanner dependency by developing a machine learning model to classify HPV status from radiological images. These experiments reveal the effect of scanner manufacturer on the robustness of radiomic features, and the extent of this dependency is reflected in the performance of HPV prediction models. The results of this study highlight the importance of implementing an appropriate approach to reducing the impact of imaging parameters on radiomic features and consequently on the machine learning models, without removing features which are deemed non-robust but may contain learning information.

Indexed as

computed tomographyhuman papillomavirusoropharyngeal cancerradiomicsrobustness

Identifiers

PMID34066857
PMCPMC8125906

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.