Evidence map›Paper›PMID 34066836›Full record

ArticleViruses2021

Efficient Intravenous Tumor Targeting Using the αvβ6 Integrin-Selective Precision Virotherapy Ad5

James A Davies, Gareth Marlow, Hanni K Uusi-Kerttula, Gillian Seaton, Luke Piggott, Luned M Badder, Richard W E Clarkson, John D Chester, Alan L Parker

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Comparison of theMolecular therapy. Oncology · 2026
    Article
  2. Review
  3. Article
  4. The αvβ6 integrin specific virotherapy, Ad5British journal of cancer · 2024
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Safe and efficientMolecular therapy. Methods & clinical development · 2022
    Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

James A DaviesDivision of Cancer and Genetics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
Gareth MarlowDivision of Cancer and Genetics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
Hanni K Uusi-KerttulaDivision of Cancer and Genetics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
Gillian SeatonSchool of Biosciences, Cardiff University, Cardiff CF24 4HQ, UK.
Luke PiggottSchool of Biosciences, Cardiff University, Cardiff CF24 4HQ, UK.
Luned M BadderDivision of Cancer and Genetics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
Richard W E ClarksonSchool of Biosciences, Cardiff University, Cardiff CF24 4HQ, UK.
John D ChesterDivision of Cancer and Genetics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
Alan L ParkerDivision of Cancer and Genetics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.ORCID 0000-0002-9302-1761
Cardiff University · GBVelindre Cancer Centre · GB

Funding

Cancer Research UK 29104Cancer Research UK C52915/A29104Cancer Research UK C7838/A25173
6 · The paper itself

Abstract

We previously developed a refined, tumor-selective adenovirus, Ad5

Indexed as

Genetic TherapyOncolytic VirotherapyAdenoviridaeAdministration, IntravenousAnimalsAntigens, NeoplasmCell Line, TumorCell SurvivalDisease Models, AnimalGenetic VectorsHumansIntegrinsMiceNeoplasmsOncolytic VirusesTransduction, GeneticAntigens, Neoplasmintegrin alphavbeta6Integrinsadenovirusoncolyticsystemic deliverytargetingvirotherapyαvβ6 integrin

Identifiers

PMID34066836
PMCPMC8151668
OpenAlexW3150227400

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.