Evidence map›Paper›PMID 34066787›Full record

ArticlePathogens (Basel, Switzerland)2021

The Synthesis and Evaluation of Multivalent Glycopeptoids as Inhibitors of the Adhesion of

Harlei Martin, Hannah Masterson, Kevin Kavanagh, Trinidad Velasco-Torrijos

Open access · goldAbstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Synthesis of mono- and di-(Frontiers in chemistry · 2026
    Article
  2. Article
  3. Pathogens (Basel, Switzerland) · 2022
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Harlei MartinDepartment of Chemistry, Maynooth University, Maynooth, W23VP22 Co. Kildare, Ireland.ORCID 0000-0002-6109-9855
Hannah MastersonDepartment of Biology, Maynooth University, Maynooth, W23VP22 Co. Kildare, Ireland.
Kevin KavanaghDepartment of Biology, Maynooth University, Maynooth, W23VP22 Co. Kildare, Ireland.
Trinidad Velasco-TorrijosDepartment of Chemistry, Maynooth University, Maynooth, W23VP22 Co. Kildare, Ireland.
National University of Ireland, Maynooth · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multivalency is a strategy commonly used by medicinal carbohydrate chemists to increase the affinity of carbohydrate-based small molecules for their protein targets. Although this approach has been very successful in enhancing binding to isolated carbohydrate-binding proteins, anticipating the multivalent presentations that will improve biological activity in cellular assays remains challenging. In this work we investigate linear molecular scaffolds for the synthesis of a low valency presentation of a divalent galactoside

Indexed as

anti-adhesion glycoconjugatesantifungal agentsCandida albicansglycomimeticsmultivalency

Identifiers

PMID34066787
PMCPMC8151480
OpenAlexW3160360656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.