Evidence map›Paper›PMID 34066716›Full record

ArticleSensors (Basel, Switzerland)2021

Digital Biomarker Representing Frailty Phenotypes: The Use of Machine Learning and Sensor-Based Sit-to-Stand Test.

Catherine Park, Ramkinker Mishra, Amir Sharafkhaneh, Mon S Bryant, Christina Nguyen, Ilse Torres, Aanand D Naik, Bijan Najafi

Open access · goldAbstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 38 citations in OpenAlex.

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  19. Cellular Senescence and Frailty in Transplantation.Current transplantation reports · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Catherine ParkInterdisciplinary Consortium on Advanced Motion Performance (iCAMP), Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
Ramkinker MishraInterdisciplinary Consortium on Advanced Motion Performance (iCAMP), Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-9441-683X
Amir SharafkhanehTelehealth Cardio-Pulmonary Rehabilitation Program, Medical Care Line, Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA.
Mon S BryantTelehealth Cardio-Pulmonary Rehabilitation Program, Medical Care Line, Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA.
Christina NguyenTelehealth Cardio-Pulmonary Rehabilitation Program, Medical Care Line, Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA.
Ilse TorresTelehealth Cardio-Pulmonary Rehabilitation Program, Medical Care Line, Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA.
Aanand D NaikVA Health Services Research and Development Center for Innovations in Quality, Effectiveness and Safety, Houston, TX 77021, USA.
Bijan NajafiInterdisciplinary Consortium on Advanced Motion Performance (iCAMP), Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-0320-8101
Baylor College of Medicine · USMichael E. DeBakey VA Medical Center · US

Funding

An Innovative Platform for Objective Monitoring of Instrumental Activities of Daily LivingR42AG060853 · NIA · BIOSENSICS, LLC · PI NGUYEN, HUNG P., VAZIRI, ASHKAN · 2018 to 2020
$4.3M
Phase II STTR: Portable Device for Telecare Monitoring of Elderly PeopleR42AG032748 · NIA · BIOSENSICS, LLC · PI GWIN, JOSEPH T, MOHLER, MARTHA JANE · 2012 to 2016
$2.7M
Portable Device for Telecare Monitoring of Elderly PeopleSB1AG032748 · NIA · BIOSENSICS, LLC · PI VAZIRI, ASHKAN · 2018 to 2019
$2.4M
NIA NIH HHS 1R42AG060853-01NIA NIH HHS 3SB1AG032748-06S1NIA NIH HHS R42AG032748U.S. Department of Veterans Affairs N/A
6 · The paper itself

Abstract

Since conventional screening tools for assessing frailty phenotypes are resource intensive and unsuitable for routine application, efforts are underway to simplify and shorten the frailty screening protocol by using sensor-based technologies. This study explores whether machine learning combined with frailty modeling could determine the least sensor-derived features required to identify physical frailty and three key frailty phenotypes (slowness, weakness, and exhaustion). Older participants (n = 102, age = 76.54 ± 7.72 years) were fitted with five wearable sensors and completed a five times sit-to-stand test. Seventeen sensor-derived features were extracted and used for optimal feature selection based on a machine learning technique combined with frailty modeling. Mean of hip angular velocity range (indicator of slowness), mean of vertical power range (indicator of weakness), and coefficient of variation of vertical power range (indicator of exhaustion) were selected as the optimal features. A frailty model with the three optimal features had an area under the curve of 85.20%, a sensitivity of 82.70%, and a specificity of 71.09%. This study suggests that the three sensor-derived features could be used as digital biomarkers of physical frailty and phenotypes of slowness, weakness, and exhaustion. Our findings could facilitate future design of low-cost sensor-based technologies for remote physical frailty assessments via telemedicine.

Indexed as

FrailtyAgedAged, 80 and overBiomarkersFrail ElderlyGeriatric AssessmentHumansMachine LearningPhenotypeBiomarkersdigital healthfrailty phenotypemachine learningolder adultsphysical frailtyremote assessmentsit-to-stand testtelemedicinewearable technology

Identifiers

PMID34066716
PMCPMC8125840
OpenAlexW3161985333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.