Evidence map›Paper›PMID 34066658›Full record

ArticleVaccines2021

Comparative Evaluation of Lumpy Skin Disease Virus-Based Live Attenuated Vaccines.

Andy Haegeman, Ilse De Leeuw, Laurent Mostin, Willem Van Campe, Laetitia Aerts, Estelle Venter, Eeva Tuppurainen, Claude Saegerman, Kris De Clercq

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
8.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 76 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Andy HaegemanInfectious Diseases in Animals, Exotic and Particular Diseases, Sciensano, Groeselenberg 99, B-1180 Brussels, Belgium.ORCID 0000-0003-4056-214X
Ilse De LeeuwInfectious Diseases in Animals, Exotic and Particular Diseases, Sciensano, Groeselenberg 99, B-1180 Brussels, Belgium.
Laurent MostinExperimental Center Machelen, Sciensano, Kerklaan 68, B-1830 Machelen, Belgium.
Willem Van CampeExperimental Center Machelen, Sciensano, Kerklaan 68, B-1830 Machelen, Belgium.
Laetitia AertsEURL for Diseases Caused by Capripox Viruses, Sciensano, Groeselenberg 99, B-1180 Brussels, Belgium.
Estelle VenterDepartment of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Onderstepoort 0110, South Africa.ORCID 0000-0001-7351-0827
Eeva TuppurainenInstitut für Internationale Tiergesundheit/One Health, Friedrich-Loeffler-Institut Federal Research Institute for Animal Health, 17489 Greifswald-Insel Riems, Germany.
Claude SaegermanFundamental and Applied Research for Animals & Health (FARAH) Center, Research Unit of Epidemiology and Risk Analysis Applied to Veterinary Sciences (UREAR-ULiège), Faculty of Veterinary Medicine, University of Liege, 4000 Liege, Belgium.ORCID 0000-0001-9087-7436
Kris De ClercqInfectious Diseases in Animals, Exotic and Particular Diseases, Sciensano, Groeselenberg 99, B-1180 Brussels, Belgium.ORCID 0000-0002-2928-3521
Sciensano (Belgium) · BEFriedrich-Loeffler-Institut · DEOnderstepoort Veterinary Academic Hospital · ZAUniversity of Liège · BE

Funding

Belgian Federal Public Service of Health, Food Chain Safety and Environment through the contract RT 15/3 (LUMPY SKIN 1)Bill and Melinda Gates Foundation Nr OPP1126866GALVmed Nr CAO-R34A0856
6 · The paper itself

Abstract

Vaccines form the cornerstone of any control, eradication and preventative strategy and this is no different for lumpy skin disease. However, the usefulness of a vaccine is determined by a multiplicity of factors which include stability, efficiency, safety and ease of use, to name a few. Although the vaccination campaign in the Balkans against lumpy skin disease virus (LSDV) was successful and has been implemented with success in the past in other countries, data of vaccine failure have also been reported. It was therefore the purpose of this study to compare five homologous live attenuated LSDV vaccines (LSDV LAV) in a standardized setting. All five LSDV LAVs studied were able to protect against a challenge with virulent LSDV. Aside from small differences in serological responses, important differences were seen in side effects such as a local reaction and a Neethling response upon vaccination between the analyzed vaccines. These observations can have important implications in the applicability in the field for some of these LSDV LAVs.

Indexed as

live attenuated vaccineslumpy skin diseaselumpy skin disease vaccinevaccine evaluation

Identifiers

PMID34066658
PMCPMC8151199
OpenAlexW3159477154

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.