Evidence map›Paper›PMID 34066615›Full record

ArticleInternational journal of environmental research and public health2021

Concurrent Heavy Metal Exposures and Idiopathic Dilated Cardiomyopathy: A Case-Control Study from the Katanga Mining Area of the Democratic Republic of Congo.

Didier Malamba-Lez, Désire Tshala-Katumbay, Virginie Bito, Jean-Michel Rigo, Richie Kipenge Kyandabike, Eric Ngoy Yolola, Philippe Katchunga, Béatrice Koba-Bora, Dophra Ngoy-Nkulu

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Blood Lead Monitoring in a Former Mining Area in Euskirchen, Germany-Volunteers across the Entire Population.International journal of environmental research and public health · 2022
    Article
  4. Social Inequalities in Non-ischemic Cardiomyopathies.Frontiers in cardiovascular medicine · 2022
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Didier Malamba-LezUnit of Training and Research in Cardiology, Department of Internal Medicine, University of Lubumbashi, Lubumbashi 07610, Democratic Republic of the Congo.ORCID 0000-0001-8414-4447
Désire Tshala-KatumbayDepartment of Neurology and School of Public Health, Oregon Health & Science University, Portland, OR 97007, USA.
Virginie BitoDoctoral School for Medicine and Life Sciences, Hasselt University, 3590 Diepenbeek, Belgium.
Jean-Michel RigoDoctoral School for Medicine and Life Sciences, Hasselt University, 3590 Diepenbeek, Belgium.ORCID 0000-0002-0031-526X
Richie Kipenge KyandabikeUnit of Training and Research in Cardiology, Department of Internal Medicine, University of Lubumbashi, Lubumbashi 07610, Democratic Republic of the Congo.ORCID 0000-0002-0143-3452
Eric Ngoy YololaUnit of Training and Research in Cardiology, Department of Internal Medicine, University of Lubumbashi, Lubumbashi 07610, Democratic Republic of the Congo.
Philippe KatchungaDepartment of Internal Medicine, Official University of Bukavu, Bukavu 11102, Democratic Republic of the Congo.
Béatrice Koba-BoraDepartment of Internal Medicine, Service of Neurology, University of Lubumbashi, Lubumbashi 07610, Democratic Republic of the Congo.
Dophra Ngoy-NkuluUnit of Training and Research in Cardiology, Department of Internal Medicine, University of Lubumbashi, Lubumbashi 07610, Democratic Republic of the Congo.
University of Lubumbashi · CDHasselt University · BEOregon Health & Science University · USUniversité Officielle de Bukavu · CD

Funding

Toxicodietary and genetic determinants of susceptibility to neurodegenerationR01ES019841 · NIEHS · OREGON HEALTH & SCIENCE UNIVERSITY · PI TSHALA-KATUMBAY, DANIEL DESIRE · 2011 to 2020
$4.6M
NIEHS NIH HHS FIC R01ES019841NIEHS NIH HHS R01 ES019841
6 · The paper itself

Abstract

Blood and/or urine levels of 27 heavy metals were determined by ICPMS in 41 patients with dilated cardiomyopathy (DCM) and 29 presumably healthy subjects from the Katanga Copperbelt (KC), in the Democratic Republic of Congo (DRC). After adjusting for age, gender, education level, and renal function, DCM probability was almost maximal for blood concentrations above 0.75 and 150 µg/dL for arsenic and copper, respectively. Urinary concentrations above 1 for chromium, 20 for copper, 600 for zinc, 30 for selenium, 2 for cadmium, 0.2 for antimony, 0.5 for thallium, and 0.05 for uranium, all in μg/g of creatinine, were also associated with increased DCM probability. Concurrent and multiple exposures to heavy metals, well beyond permissible levels, are associated with increased probability for DCM. Study findings warrant screening for metal toxicity in case of DCM and prompt public health measures to reduce exposures in the KC, DRC.

Indexed as

ArsenicCardiomyopathy, DilatedMetals, HeavyCase-Control StudiesDemocratic Republic of the CongoEnvironmental ExposureHumansZambiaArsenicMetals, Heavyenvironmental exposuresheavy metalsidiopathic dilated cardiomyopathyKatanga Copperbelt

Identifiers

PMID34066615
PMCPMC8124897
OpenAlexW3154908224

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.