Evidence map›Paper›PMID 34066587›Full record

ReviewAntibiotics (Basel, Switzerland)2021

Pollution by Antibiotics and Antimicrobial Resistance in LiveStock and Poultry Manure in China, and Countermeasures.

Ming Tian, Xinmiao He, Yanzhong Feng, Wentao Wang, Heshu Chen, Ming Gong, Di Liu, Jihong Liu Clarke, André van Eerde

Open access · goldAbstract readReview
In one paragraph

Review in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 1 pooled it
8.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 1 synthesis or guideline pooled it, 253 citations in OpenAlex.

  1. Pooled it
  2. Applied and environmental microbiology · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Wastewater Treatment Challenges and Circular Reuse for One Health Sustainability: A Review.International journal of environmental research and public health · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Visible light active BiBMC chemistry · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Antibiotic resistance dissemination in soil ecosystems: deep understanding for effective management and global health protection.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
  17. Article
  18. Article
  19. Article
  20. Synergistic Effects of Sanguinarine andVeterinary sciences · 2026
    Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Ming TianInstitute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Harbin 150086, China.
Xinmiao HeInstitute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Harbin 150086, China.
Yanzhong FengInstitute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Harbin 150086, China.
Wentao WangInstitute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Harbin 150086, China.
Heshu ChenInstitute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Harbin 150086, China.
Ming GongThe Breeding Center of Felid of Hengdao He Zi (Heilong Jiang) China, Siberia Tiger Park Heilongjiang, Harbin 150086, China.
Di LiuInstitute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Harbin 150086, China.
Jihong Liu ClarkeNIBIO, Norwegian Institute of Bioeconomy Research, P.O. Box 115, NO-1431 Ås, Norway.ORCID 0000-0002-4924-0406
André van EerdeNIBIO, Norwegian Institute of Bioeconomy Research, P.O. Box 115, NO-1431 Ås, Norway.
Animal Science Research Institute · CNNorwegian Institute of Bioeconomy Research · NOEducation Department of Heilongjiang Province · CN

Funding

Heilongjiang Academy of Agricultural Sciences 2019JJPY01Heilongjiang Province CZKYF2020A004Heilongjiang Province and the Chinese Academy of Sciences and the Chinese Academy of Engineering YS19C07National Natural Science Foundation of China 31872980National Natural Science Foundation of China U20a2052Norwegian Ministry of Foreign Affairs CHN 2152, 17/0019
6 · The paper itself

Abstract

The demand for animal protein has increased considerably worldwide, especially in China, where large numbers of livestock and poultry are produced. Antibiotics have been widely applied to promote growth and prevent diseases. However, the overuse of antibiotics in animal feed has caused serious environmental and health risks, especially the wide spread of antimicrobial resistance (AMR), which seriously affects animal and human health, food safety, ecosystems, and the sustainable future development of animal protein production. Unfortunately, AMR has already become a worldwide challenge, so international cooperation is becoming more important for combatting it. China's efforts and determination to restrict antibiotic usage through law enforcement and effective management are of significance. In this review, we address the pollution problems of antibiotics; in particular, the AMR in water, soil, and plants caused by livestock and poultry manure in China. The negative impact of widespread and intensive use of antibiotics in livestock production is discussed. To reduce and mitigate AMR problems, we emphasize in this review the development of antibiotic substitutes for the era of antibiotic prohibition.

Indexed as

antibioticsantimicrobial resistance (AMR)bacteriaChinahuman and animal healthlivestock and poultry manure

Identifiers

PMID34066587
PMCPMC8148549
OpenAlexW3157877016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.