Evidence map›Paper›PMID 34066555›Full record

ReviewInternational journal of molecular sciences2021

Strategies to Tackle Antimicrobial Resistance: The Example of

Giada Antonelli, Luigia Cappelli, Paolo Cinelli, Rossella Cuffaro, Benedetta Manca, Sonia Nicchi, Serena Tondi, Giacomo Vezzani, Viola Viviani, Isabel Delany and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Polyphenol Analysis and Antibacterial Potentials of Twig Extracts ofInternational journal of molecular sciences · 2024
    Article
  9. Review
  10. Molecular Signature of Monocytes Shaped by theInternational journal of molecular sciences · 2024
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. What Is New in the Anti-Frontiers in cellular and infection microbiology · 2022
    Review
  18. DissectingFrontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Giada AntonelliGSK Vaccines, 53100 Siena, Italy.
Luigia CappelliGSK Vaccines, 53100 Siena, Italy.ORCID 0000-0002-3991-3611
Paolo CinelliGSK Vaccines, 53100 Siena, Italy.
Rossella CuffaroGSK Vaccines, 53100 Siena, Italy.
Benedetta MancaGSK Vaccines, 53100 Siena, Italy.
Sonia NicchiGSK Vaccines, 53100 Siena, Italy.
Serena TondiGSK Vaccines, 53100 Siena, Italy.
Giacomo VezzaniGSK Vaccines, 53100 Siena, Italy.ORCID 0000-0003-1142-598X
Viola VivianiGSK Vaccines, 53100 Siena, Italy.
Isabel DelanyGSK Vaccines, 53100 Siena, Italy.
Maria ScarselliGSK Vaccines, 53100 Siena, Italy.
Francesca SchiavettiGSK Vaccines, 53100 Siena, Italy.
University of Bologna · ITUniversity of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traditional antimicrobial treatments consist of drugs which target different essential functions in pathogens. Nevertheless, bacteria continue to evolve new mechanisms to evade this drug-mediated killing with surprising speed on the deployment of each new drug and antibiotic worldwide, a phenomenon called antimicrobial resistance (AMR). Nowadays, AMR represents a critical health threat, for which new medical interventions are urgently needed. By 2050, it is estimated that the leading cause of death will be through untreatable AMR pathogens. Although antibiotics remain a first-line treatment, non-antibiotic therapies such as prophylactic vaccines and therapeutic monoclonal antibodies (mAbs) are increasingly interesting alternatives to limit the spread of such antibiotic resistant microorganisms. For the discovery of new vaccines and mAbs, the search for effective antigens that are able to raise protective immune responses is a challenging undertaking. In this context, outer membrane vesicles (OMV) represent a promising approach, as they recapitulate the complete antigen repertoire that occurs on the surface of Gram-negative bacteria. In this review, we present

Indexed as

Drug Resistance, BacterialAnimalsBacterial VaccinesEscherichia coliEscherichia coli InfectionsHumansPseudomonas aeruginosaPseudomonas InfectionsBacterial Vaccinesantigen identificationantimicrobial resistance (AMR)Escherichia colimonoclonal antibodies (mAbs)outer membrane vesicles (OMV)Pseudomonas aeruginosavaccine

Identifiers

PMID34066555
PMCPMC8125385
OpenAlexW3159009258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.