Evidence map›Paper›PMID 34066407›Full record

ArticleBiomedicines2021

Anti-Inflammatory Effects of Dietary Plant Stanol Supplementation Are Largely Dependent on the Intake of Cholesterol in a Mouse Model of Metabolic Inflammation.

Inês Magro Dos Reis, Tom Houben, Marion J J Gijbels, Dieter Lütjohann, Jogchum Plat, Ronit Shiri-Sverdlov

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Inês Magro Dos ReisDepartment of Molecular Genetics, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, 6229 ER Maastricht, The Netherlands.
Tom HoubenDepartment of Molecular Genetics, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, 6229 ER Maastricht, The Netherlands.ORCID 0000-0002-0441-3166
Marion J J GijbelsDepartment of Pathology, Cardiovascular Research Institute Maastricht (CARIM,), School for Oncology and Developmental Biology (GROW), Maastricht University, 6229 ER Maastricht, The Netherlands.ORCID 0000-0002-4906-0384
Dieter LütjohannInstitute of Clinical Chemistry and Clinical Pharmacology, Venusberg-Campus 1, University Hospital Bonn, D-53127 Bonn, Germany.ORCID 0000-0002-7941-8308
Jogchum PlatDepartment of Nutrition and Movement Sciences, School for Nutrition, Toxicology and Metabolism (NUTRIM), Maastricht University, 6229 ER Maastricht, The Netherlands.
Ronit Shiri-SverdlovDepartment of Molecular Genetics, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, 6229 ER Maastricht, The Netherlands.ORCID 0000-0002-6736-7814
Maastricht University · NLUniversity Hospital Bonn · DE

Funding

Topconsortium voor Kennis en Innovatie 40-41200-98-9306
6 · The paper itself

Abstract

The prevalence of metabolic disorders characterized by chronic inflammation has been on a sharp rise for decades. As such, tools that address metabolic and inflammatory dysregulation are of great importance. Plant stanols are well-known for reducing intestinal cholesterol absorption and may also have direct anti-inflammatory effects. In this study, our aim was to investigate to what extent the benefits of dietary plant stanol supplementation depend on dietary cholesterol intake in an experimental mouse model for cholesterol-induced metabolic inflammation. Here, we used

Indexed as

cholesteroldiethepatic inflammationplant stanols

Identifiers

PMID34066407
PMCPMC8148209
OpenAlexW3161966559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.