Evidence map›Paper›PMID 34066352›Full record

ArticleJournal of personalized medicine2021

Cerebral Vasoreactivity Evaluated by Transcranial Color Doppler and Breath-Holding Test in Patients after SARS-CoV-2 Infection.

Marino Marcic, Ljiljana Marcic, Barbara Marcic, Vesna Capkun, Katarina Vukojevic

Abstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Review
  8. Cardiovascular and cerebral vascular health in females with postacute sequelae of COVID-19.American journal of physiology. Heart and circulatory physiology · 2023
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  12. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marino MarcicDepartment of Neurology, University Hospital Center Split, 21000 Split, Croatia.
Ljiljana MarcicDepartment of Radiology, Polyclinic Medicol, 2100 Split, Croatia.
Barbara MarcicDepartment of Medical Genetics, University of Mostar School of Medicine, 88000 Mostar, Bosnia and Herzegovina.
Vesna CapkunDepartment of Anatomy, Histology and Embryology, University of Split School of Medicine, 21000 Split, Croatia.
Katarina VukojevicDepartment of Medical Genetics, University of Mostar School of Medicine, 88000 Mostar, Bosnia and Herzegovina.ORCID 0000-0003-2182-2890

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

From the beginning of the SARS-CoV-2 virus pandemic, it was clear that the virus is highly neurotrophic. Neurological manifestations can range from nonspecific symptoms such as dizziness, headaches and olfactory disturbances to severe forms of neurological dysfunction. Some neurological complication can occur even after mild forms of respiratory disease. This study's aims were to assess cerebrovascular reactivity in patients with nonspecific neurological symptoms after SARS-CoV-2 infection. A total of 25 patients, aged 33-62 years, who had nonspecific neurological symptoms after SARS-CoV-2 infection, as well as 25 healthy participants in the control group, were assessed for cerebrovascular reactivity according to transcranial color Doppler (TCCD) which we combined with a breath-holding test (BHT). In subjects after SARS-CoV-2 infection, there were statistically significantly lower flow velocities through the middle cerebral artery at rest period, lower maximum velocities at the end of the breath-holding period and lower breath holding index (BHI) in relation to the control group. Changes in cerebral artery flow rate velocities indicate poor cerebral vasoreactivity in the group after SARS-CoV-2 infection in regard to the control group and suggest vascular endothelial damage by the SARS-CoV-2 virus.

Indexed as

nonspecific neurological symptomsSARS-CoV-2transcranial color Dopplervasoreactivity

Identifiers

PMID34066352
PMCPMC8148160

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.