Evidence map›Paper›PMID 34066341›Full record

ArticlePharmaceutics2021

The Biological Effects of Novel Nutraceuticals with Curcuminoids and Other Plant-Derived Immunomodulators and Pre-Probiotics.

Adina Elena Răducanu, Bianca-Maria Tihăuan, Ioana Cristina Marinaș, Oana Teodora Ciupercă, Carmen Elena Țebrencu, Elena Ionescu, Tatiana Onisei

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Bioactive Compounds from Vegetal Organs ofInternational journal of molecular sciences · 2025
    Review
  3. Article
  4. Natural Ingredients to Improve Immunity.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Adina Elena RăducanuResearch and Development Department, The National Institute for Research and Development in Food Bioresources, Str. Dinu Vintilă, No.6, 021102 Bucharest, Romania.
Bianca-Maria TihăuanResearch and Development Department, The National Institute for Research and Development in Food Bioresources, Str. Dinu Vintilă, No.6, 021102 Bucharest, Romania.ORCID 0000-0001-6288-0267
Ioana Cristina MarinașResearch Institute of the University of Bucharest-ICUB, 91-95 Spl. Independentei, 50567 Bucharest, Romania.ORCID 0000-0002-7342-5398
Oana Teodora CiupercăFaculty of Chemical Engineering and Environmental Protection "Cristofor Simionescu", "Gheorghe Asachi" Technical University of Iași, 73, Prof. Dr. Docent D. Mangeron Street, 700050 Iași, Romania.
Carmen Elena ȚebrencuResearch and Processing Centre for Medicinal Plants "PLANTAVOREL" S.A., 46, Cuza Voda Street, 610019 Piatra Neamţ, Romania.
Elena IonescuResearch and Processing Centre for Medicinal Plants "PLANTAVOREL" S.A., 46, Cuza Voda Street, 610019 Piatra Neamţ, Romania.
Tatiana OniseiResearch and Development Department, The National Institute for Research and Development in Food Bioresources, Str. Dinu Vintilă, No.6, 021102 Bucharest, Romania.
Academia Oamenilor de Știință din România · ROUniversity of Bucharest · ROGheorghe Asachi Technical University of Iași · RO

Funding

European funding programme POC-A1-A1.2.3-G-2015, ID_40_404, MySMIS code 105509 "Exploiting expertise in agro-food research by transferring knowledge to the private environment in order to obtain safe and nutritionally optimized food products" acronym EXPERTAL, Financing Agreement no. 57 / 05.09.2017, Subsidiary Contract Type D no. 1
6 · The paper itself

Abstract

An effective and well-balanced immune system is pivotal for maintaining health. Diet and nutrition can affect the functioning of numerous immune parameters, with direct repercussions on homeostasis. Since our immune functions are indispensable in defending the body against pathogens and thus play a vital role in maintaining health, modulating immune response may well serve as the basis for the development of plant-based functional foods and novel nutraceuticals. This concept is currently utilized in attempts to prevent or mitigate inflammatory reactions via the development of targeted food products or active ingredients since an extended number of phytoconstituents (such as curcuminoids) are associated with beneficial effects on immunity. Immunomodulatory plant-based dietary supplements are considered effective in improving immune functions and reducing the incidence of immunological disorders or imbalances. Therefore, the main focus of this study was to evidence the beneficial biological effects such as antioxidant and antimicrobial, as well as nutritional status, biocompatibility and cell proliferation capacity and immunomodulation of two novel nutraceuticals. The first nutraceutic was based on curcuminoids and other actives from

Indexed as

antimicrobialcytotoxicnovel nutraceuticalsplant-based immunomodulatorspre-probiotics

Identifiers

PMID34066341
PMCPMC8148190
OpenAlexW3157465634

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.