Evidence map›Paper›PMID 34066075›Full record

ReviewNutrients2021

Diversity of Plant Sterols Metabolism: The Impact on Human Health, Sport, and Accumulation of Contaminating Sterols.

Arthur T Kopylov, Kristina A Malsagova, Alexander A Stepanov, Anna L Kaysheva

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Saskatoon berry (Food science and biotechnology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Aspects of β-sitosterol's Pharmacology, Nutrition and Analysis.Current pharmaceutical biotechnology · 2025
    Review
  8. Effectiveness effects ofOpen veterinary journal · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. The desert woodrat (Neotoma lepida) induces a diversity of biotransformation genes in response to creosote bush resin.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2024
    Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Phytosterols: Potential Metabolic Modulators in Neurodegenerative Diseases.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Arthur T KopylovInstitute of Biomedical Chemistry, Group of Biobanking, 10 Pogodinskaya Str., Bld. 8, 119121 Moscow, Russia.ORCID 0000-0002-7199-372X
Kristina A MalsagovaInstitute of Biomedical Chemistry, Group of Biobanking, 10 Pogodinskaya Str., Bld. 8, 119121 Moscow, Russia.
Alexander A StepanovInstitute of Biomedical Chemistry, Group of Biobanking, 10 Pogodinskaya Str., Bld. 8, 119121 Moscow, Russia.ORCID 0000-0002-9113-9440
Anna L KayshevaInstitute of Biomedical Chemistry, Group of Biobanking, 10 Pogodinskaya Str., Bld. 8, 119121 Moscow, Russia.ORCID 0000-0003-4472-2016
Institute of Biomedical Chemistry · RU

Funding

World-Class Research Centers "Digital biodesign and personalized healthcare" 075-15-2020-913
6 · The paper itself

Abstract

The way of plant sterols transformation and their benefits for humans is still a question under the massive continuing revision. In fact, there are no receptors for binding with sterols in mammalians. However, possible biotransformation to steroids that can be catalyzed by gastro-intestinal microflora, microbial cells in prebiotics or cytochromes system were repeatedly reported. Some products of sterols metabolization are capable to imitate resident human steroids and compete with them for the binding with corresponding receptors, thus affecting endocrine balance and entire physiology condition. There are also tremendous reports about the natural origination of mammalian steroid hormones in plants and corresponding receptors for their binding. Some investigations and reports warn about anabolic effect of sterols, however, there are many researchers who are reluctant to believe in and have strong opposing arguments. We encounter plant sterols everywhere: in food, in pharmacy, in cosmetics, but still know little about their diverse properties and, hence, their exact impact on our life. Most of our knowledge is limited to their cholesterol-lowering influence and protective effect against cardiovascular disease. However, the world of plant sterols is significantly wider if we consider the thousands of publications released over the past 10 years.

Indexed as

Athletic PerformanceBiotransformationHealth StatusHumansPlantsSterolsSterolsanabolic effectbiotransformationcholesteroldietfood matrixsterols

Identifiers

PMID34066075
PMCPMC8150896
OpenAlexW3161577949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.