Evidence map›Paper›PMID 34065995›Full record

ArticleCancers2021

Factors Influencing the Adjuvant Therapy Decision: Results of a Real-World Multicenter Data Analysis of 904 Melanoma Patients.

Georg Lodde, Andrea Forschner, Jessica Hassel, Lena M Wulfken, Friedegund Meier, Peter Mohr, Katharina Kähler, Bastian Schilling, Carmen Loquai, Carola Berking and 16 more

Abstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Georg LoddeDepartment of Dermatology, Venereology and Allergology, University Hospital Essen, 45147 Essen, Germany.
Andrea ForschnerDepartment of Dermatology, University Hospital Tuebingen, 72076 Tuebingen, Germany.ORCID 0000-0002-6185-4945
Jessica HasselDepartment of Dermatology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Lena M WulfkenSkin Cancer Center Hannover, Department of Dermatology and Allergy, Venereology and Allergology, University Hospital Hannover Medical School, 30625 Hannover, Germany.
Friedegund MeierSkin Cancer Center at the University Cancer Centre Dresden and National Center for Tumor Diseases, 01307 Dresden, Germany.
Peter MohrDepartment of Dermatology, Elbe Kliniken Stade-Buxtehude, 21614 Buxtehude, Germany.
Katharina KählerDepartment of Dermatology, Venereology and Allergology, University Hospital Kiel, 24105 Kiel, Germany.
Bastian SchillingDepartment of Dermatology, Venereology and Allergology, University Hospital Wuerzburg, 97080 Wuerzburg, Germany.ORCID 0000-0001-8859-4103
Carmen LoquaiDepartment of Dermatology, University Hospital Mainz, 55131 Mainz, Germany.
Carola BerkingDepartment of Dermatology, University Hospital Erlangen, CCC-Comprehensive Cancer Center Erlangen-EMN, Erlangen, Friedrich-Alexander University Erlangen-Nuremberg (FAU), Deutsches Zentrum Immuntherapie (DZI), 91054 Erlangen, Germany.
Svea HüningDepartment of Dermatology, Klinikum Dortmund gGmbH, 44137 Dortmund, Germany.
Kerstin SchattonDepartment of Dermatology, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany.
Christoffer GebhardtDepartment of Dermatology, Venereology and Allergology, University Hospital Hamburg, 20246 Hamburg, Germany.ORCID 0000-0001-7090-9584
Julia EckardtDepartment of Dermatology, University Hospital Tuebingen, 72076 Tuebingen, Germany.
Ralf GutzmerSkin Cancer Center Hannover, Department of Dermatology and Allergy, Venereology and Allergology, University Hospital Hannover Medical School, 30625 Hannover, Germany.
Lydia ReinhardtSkin Cancer Center at the University Cancer Centre Dresden and National Center for Tumor Diseases, 01307 Dresden, Germany.ORCID 0000-0001-6232-5132
Valerie GlutschDepartment of Dermatology, Venereology and Allergology, University Hospital Wuerzburg, 97080 Wuerzburg, Germany.
Ulrike NikfarjamDepartment of Dermatology, University Hospital Mainz, 55131 Mainz, Germany.
Michael ErdmannDepartment of Dermatology, University Hospital Erlangen, CCC-Comprehensive Cancer Center Erlangen-EMN, Erlangen, Friedrich-Alexander University Erlangen-Nuremberg (FAU), Deutsches Zentrum Immuntherapie (DZI), 91054 Erlangen, Germany.ORCID 0000-0001-7136-6489
Andreas StangInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, 45122 Essen, Germany.ORCID 0000-0001-6363-9061
Bernd KowallInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, 45122 Essen, Germany.
Alexander RoeschDepartment of Dermatology, Venereology and Allergology, University Hospital Essen, 45147 Essen, Germany.
Selma UgurelDepartment of Dermatology, Venereology and Allergology, University Hospital Essen, 45147 Essen, Germany.ORCID 0000-0002-9384-6704
Lisa ZimmerDepartment of Dermatology, Venereology and Allergology, University Hospital Essen, 45147 Essen, Germany.
Dirk SchadendorfDepartment of Dermatology, Venereology and Allergology, University Hospital Essen, 45147 Essen, Germany.ORCID 0000-0003-3524-7858
Elisabeth LivingstoneDepartment of Dermatology, Venereology and Allergology, University Hospital Essen, 45147 Essen, Germany.ORCID 0000-0001-8279-9239

Funding

DFG, German Research Foundation RTG 2535
6 · The paper itself

Abstract

Adjuvant treatment of melanoma patients with immune-checkpoint inhibition (ICI) and targeted therapy (TT) significantly improved recurrence-free survival. This study investigates the real-world situation of 904 patients from 13 German skin cancer centers with an indication for adjuvant treatment since the approval of adjuvant ICI and TT. From adjusted log-binomial regression models, we estimated relative risks for associations between various influence factors and treatment decisions (adjuvant therapy yes/no, TT vs. ICI in

Indexed as

adjuvant treatmentBRAFcheckpoint blockermelanomaPD-1targeted therapy

Identifiers

PMID34065995
PMCPMC8151445

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.