Evidence map›Paper›PMID 34065941›Full record

ArticleBiomolecules2021

Cytotoxic Compounds of Two Demosponges (

Maria Orfanoudaki, Anja Hartmann, Mostafa Alilou, Naida Mehic, Marcel Kwiatkowski, Karin Jöhrer, Hieu Nguyen Ngoc, Andreas Hensel, Richard Greil, Markus Ganzera

Abstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Afil, a Lectin fromMicroorganisms · 2025
    Article
  3. Article
  4. Marine drugs · 2024
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maria OrfanoudakiInstitute of Pharmacy/Pharmacognosy, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.ORCID 0000-0002-9409-7645
Anja HartmannInstitute of Pharmacy/Pharmacognosy, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.
Mostafa AlilouInstitute of Pharmacy/Pharmacognosy, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.
Naida MehicInstitute of Pharmacy/Pharmacognosy, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.
Marcel KwiatkowskiFunctional Proteo-Metabolomics, Department of Biochemistry, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.ORCID 0000-0002-5804-6031
Karin JöhrerTyrolean Cancer Research Institute, 6020 Innsbruck, Austria.ORCID 0000-0002-6400-6175
Hieu Nguyen NgocFaculty of Pharmacy, Phenikaa University, Hanoi 12116, Vietnam.ORCID 0000-0002-7558-419X
Andreas HenselInstitute of Pharmaceutical Biology and Phytochemistry, University of Münster, Corrensstraße 48, 48149 Münster, Germany.
Richard GreilTyrolean Cancer Research Institute, 6020 Innsbruck, Austria.ORCID 0000-0002-4462-3694
Markus GanzeraInstitute of Pharmacy/Pharmacognosy, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.ORCID 0000-0002-7407-9060

Funding

Austrian Science Fund P29671
6 · The paper itself

Abstract

The class of demosponges is the biggest and most diverse of all described sponge species and it is reported to produce a plethora of chemically different metabolites with interesting biological activities. The focus of the present study was to investigate the chemical composition of two Mediterranean demosponges, targeting their brominated compounds and prenylated hydroquinones, compounds with interesting cytotoxic and anti-microbial properties. In order to gain a deeper insight into the chemical diversity of their metabolites and their activities, 20 pure secondary metabolites including new natural products were isolated from two different species (

Indexed as

AnimalsBiological ProductsCell Line, TumorChromatography, High Pressure LiquidCytotoxinsHumansLeukocytes, MononuclearMagnetic Resonance SpectroscopyNeoplasmsPoriferaBiological ProductsCytotoxinsantimicrobial agentsAplysina aerophobabrominated compoundscytotoxicityprenylated hydroquinonesSpongia sp.

Identifiers

PMID34065941
PMCPMC8151441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.