Evidence map›Paper›PMID 34065885›Full record

ArticleInternational journal of molecular sciences2021

Human Indoleamine 2,3-dioxygenase 1 (IDO1) Expressed in Plant Cells Induces Kynurenine Production.

Michele Bellucci, Andrea Pompa, Carine De Marcos Lousa, Eleonora Panfili, Elena Orecchini, Elisa Maricchiolo, Daniele Fraternale, Ciriana Orabona, Francesca De Marchis, Maria Teresa Pallotta

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Frontiers in bioengineering and biotechnology · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Decoding the Complex Crossroad of Tryptophan Metabolic Pathways.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Michele BellucciInstitute of Biosciences and Bioresources, National Research Council of Italy, 06128 Perugia, Italy.ORCID 0000-0001-7476-9603
Andrea PompaInstitute of Biosciences and Bioresources, National Research Council of Italy, 06128 Perugia, Italy.ORCID 0000-0001-9884-5607
Carine De Marcos LousaCentre for Biomedical Sciences, School of Clinical and Applied Sciences, Leeds Beckett University, Leeds LS13HE, UK.ORCID 0000-0002-5041-6261
Eleonora PanfiliDepartment of Medicine and Surgery, University of Perugia, 06128 Perugia, Italy.
Elena OrecchiniDepartment of Medicine and Surgery, University of Perugia, 06128 Perugia, Italy.ORCID 0000-0003-1872-4042
Elisa MaricchioloDepartment of Biomolecular Sciences, University Carlo Bo, 61029 Urbino, Italy.
Daniele FraternaleDepartment of Biomolecular Sciences, University Carlo Bo, 61029 Urbino, Italy.ORCID 0000-0002-8489-4747
Ciriana OrabonaDepartment of Medicine and Surgery, University of Perugia, 06128 Perugia, Italy.ORCID 0000-0003-3113-0572
Francesca De MarchisInstitute of Biosciences and Bioresources, National Research Council of Italy, 06128 Perugia, Italy.ORCID 0000-0002-1561-369X
Maria Teresa PallottaDepartment of Medicine and Surgery, University of Perugia, 06128 Perugia, Italy.ORCID 0000-0002-0417-1638
University of Perugia · ITUniversity of Urbino · ITInstitute of Biosciences and Bioresources · ITUniversity of Leeds · GB

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca (MIUR) PRIN2017 WJZ9W9
6 · The paper itself

Abstract

Genetic engineering of plants has turned out to be an attractive approach to produce various secondary metabolites. Here, we attempted to produce kynurenine, a health-promoting metabolite, in plants of

Indexed as

Agrobacterium tumefaciensCloning, MolecularGreen Fluorescent ProteinsHumansIndoleamine-Pyrrole 2,3,-DioxygenaseKynurenineNicotianaPlasmidsProtein StabilityRecombinant ProteinsTransformation, BacterialGreen Fluorescent ProteinsIDO1 protein, humanIndoleamine-Pyrrole 2,3,-DioxygenaseKynurenineRecombinant Proteinsgenetic transformationkynurenineprotoplasts

Identifiers

PMID34065885
PMCPMC8151846
OpenAlexW3163923033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.