Evidence map›Paper›PMID 34065795›Full record

ReviewJournal of personalized medicine2021

Breast Cancer-Related Lymphedema: Recent Updates on Diagnosis, Severity and Available Treatments.

Marco Pappalardo, Marta Starnoni, Gianluca Franceschini, Alessio Baccarani, Giorgio De Santis

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 36 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 5 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07154043 narecruitingnot on this mapstarted 2025, after this paper: background citation

Comparison of Intermittent Pneumatic Compression Therapy as an Alternative or an Adjunct to Manual Lymphatic Drainage Within Complete Decongestive Therapy for Breast Cancer-Related Lymphedema

TypeinterventionalSponsorPamukkale UniversityRan2025 to 2026Enrolled45ConditionsBreast Cancer-Related Lymphedema, BCRLArmsComplete Decongestive Therapy (CDT), CDT + Intermittent Pneumatic Compression (IPC), CDT without Manual Lymph Drainage plus Intermittent Pneumatic Compression
NCT07154771 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Development and Usability Evaluation of an Arm Circumference Measurement Tool For Patients Undergoing Breast Surgery

TypeinterventionalSponsorSaglik Bilimleri Universitesi Gulhane Tip FakultesiRan2025 to 2025Enrolled35ConditionsBreast Surgery, Breast Cancer, LymphedemaArmsFirst with the arm circumference measurement tool, then with the traditional tape measure, First with the traditional tape measure , then with the arm circumference measurement tool
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 5 syntheses or guidelines pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Review
  7. Effective Treatment Approaches for Breast Cancer-Related Lymphedema.Journal of plastic and reconstructive surgery · 2026
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. A Co-design of a digital platform to support self-management of breast cancer-related lymphoedema.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Letter to the editor: "Association between chemotherapy and the risk of developing breast cancer-related lymphedema: a nationwide retrospective cohort study".Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  19. Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Marco PappalardoDivision of Plastic and Reconstructive Surgery, Department of Medical and Surgical Sciences, Modena Policlinico Hospital, University of Modena and Reggio Emilia, 41124 Modena, Italy.ORCID 0000-0003-4911-9523
Marta StarnoniDivision of Plastic and Reconstructive Surgery, Department of Medical and Surgical Sciences, Modena Policlinico Hospital, University of Modena and Reggio Emilia, 41124 Modena, Italy.
Gianluca FranceschiniMultidisciplinary Breast Center, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Largo A. Gemelli, 8-00168 Rome, Italy.ORCID 0000-0002-2950-3395
Alessio BaccaraniDivision of Plastic and Reconstructive Surgery, Department of Medical and Surgical Sciences, Modena Policlinico Hospital, University of Modena and Reggio Emilia, 41124 Modena, Italy.
Giorgio De SantisDivision of Plastic and Reconstructive Surgery, Department of Medical and Surgical Sciences, Modena Policlinico Hospital, University of Modena and Reggio Emilia, 41124 Modena, Italy.
University of Modena and Reggio Emilia · ITUniversità Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer-related lymphedema (BCRL) represents a global healthcare issue affecting the emotional and life quality of breast cancer survivors significantly. The clinical presentation is characterized by swelling of the affected upper limb, that may be accompanied by atrophic skin findings, pain and recurrent cellulitis. Cardinal principles of lymphedema management are the use of complex decongestive therapy and patient education. Recently, new microsurgery procedures have been reported with interesting results, bringing in a new opportunity to care postmastectomy lymphedema. However, many aspects of the disease are still debated in the medical community, including clinical examination, imaging techniques, patient selection and proper treatment. Here we will review these aspects and the current literature.

Indexed as

breast cancerlymphatic microsurgerylymphaticovenous anastomosislymphedemaradiotherapyvascularized lymph node transfer

Identifiers

PMID34065795
PMCPMC8151072
OpenAlexW3161111578

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.