ReviewJournal of clinical medicine2021
Uric Acid-An Emergent Risk Marker for Thrombosis?
Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- PECSS: Pulmonary Embolism Comprehensive Screening Score to safely rule out pulmonary embolism among suspected patients presenting to emergency department.BMC pulmonary medicine · 2023Trial
- Evaluation of the Pulmonary Embolism Comprehensive Screening Scoring (PECSS) using multi-center emergency cohorts.Journal of thrombosis and thrombolysis · 2026Article
- Article
- A 34-Year-Old Man With Exercise-Induced ST-Segment Elevation Myocardial Infarction 36 Hours After Descent From High Altitude: A Case Report.The American journal of case reports · 2026Article
- Exploring the modulatory effects of spotted pumpkin (Translational animal science · 2026Article
- Association of Baseline Serum Uric Acid With Venous Thromboembolism and Clinical Outcomes in Patients With Non-Small Cell Lung Cancer.Thoracic cancer · 2025Article
- Gout in pregnancy: Obstetric and neonatal outcomes.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Article
- Multiple cardioembolic attacks with a huge ventricular thrombus in dilated cardiomyopathy: A case report and comprehensive review.The Journal of international medical research · 2025Review
- The impact of inflammatory factors on patients with concurrent lung cancer and acute pulmonary embolism.Frontiers in cardiovascular medicine · 2025Article
- Clinical characteristics of pulmonary embolism at extremely high altitude: a single-center retrospective study.Frontiers in public health · 2025Article
- Gender-specific relationships between hyperuricemia and idiopathic deep venous thrombosis in the Chinese population: a case‒control study.Thrombosis journal · 2024Article
- Relationship between serum uric acid levels and pulmonary embolism: an age-based stratified analysis.Thrombosis journal · 2024Article
- Association of platelet to high-density lipoprotein cholesterol ratio with hyperuricemia.Scientific reports · 2024Article
- A new nomogram prediction model for pulmonary embolism in older hospitalized patients.Heliyon · 2024Article
- A nomogram to predict ventricular thrombus in dilated cardiomyopathy patients.Journal of thrombosis and thrombolysis · 2024Article
- Association of Serum Uric Acid with Non-Valvular Atrial Fibrillation: A Retrospective Study in China.International journal of general medicine · 2024Article
- Insights into the relationship between serum uric acid and pulmonary hypertension (Review).Molecular medicine reports · 2024Review
- The Combination of Uric Acid and Hemoglobin Levels Predicts the Incident Risk of Ischemic Heart Disease More Than Uric Acid Alone in Non-Diabetic Koreans: A Longitudinal Study Using National Health Insurance Data.Journal of personalized medicine · 2023Article
- Association between uric acid and risk of venous thromboembolism in East Asian populations: a cohort and Mendelian randomization study.The Lancet regional health. Western Pacific · 2023Article
- A Mendelian randomization study of serum uric acid with the risk of venous thromboembolism.Arthritis research & therapy · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperuricemia is nowadays an established cardiovascular risk factor. Experimental studies linked elevated serum uric acid (SUA) levels with endothelial dysfunction (ED), inflammation, and prothrombotic state. The purpose of this review is to summarize the current evidence that emphasizes the possible role of uric acid as a biomarker for a prothrombotic state. A large number of clinical trials correlated SUA levels with both incident and recurrent cases of venous thromboembolism (VTE), independent of other confounding risk factors. Moreover, increased SUA levels may be an important tool for the risk stratification of patients with pulmonary embolism (PE). Left atrial thrombosis was correlated with high SUA levels in several studies and its addition to classical risk scores improved their predictive abilities. In patients with acute myocardial infarction (MI), hyperuricemia was associated with increased mortality, and the idea that hyperuricemia may be able to act as a surrogate to unstable coronary plaques was advanced. Finally, SUA was correlated with an increased risk of thromboembolic events in different systemic diseases. In conclusion, uric acid has been considered a marker of a thrombotic milieu in several clinical scenarios. However, this causality is still controversial, and more experimental and clinical data is needed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.