Evidence map›Paper›PMID 34065787›Full record

ArticleJournal of personalized medicine2021

Creating a 'Molecular Band-Aid'; Blocking an Exposed Protease Target Site in Desmoplakin.

Catherine A Hoover, Kendahl L Ott, Heather R Manring, Trevor Dew, Maegen A Borzok, Nathan T Wright

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Calpain Regulation and Dysregulation-Its Effects on the Intercalated Disk.International journal of molecular sciences · 2023
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Catherine A HooverDepartment of Natural Sciences, Mansfield University of Pennsylvania, Mansfield, PA 16933, USA.
Kendahl L OttDepartment of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA 22807, USA.
Heather R ManringDepartment of Physiology and Cell Biology, Wexner Medical Center, Ohio State University, Columbus, OH 43210, USA.
Trevor DewDepartment of Physiology and Cell Biology, Wexner Medical Center, Ohio State University, Columbus, OH 43210, USA.
Maegen A BorzokDepartment of Natural Sciences, Mansfield University of Pennsylvania, Mansfield, PA 16933, USA.
Nathan T WrightDepartment of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA 22807, USA.
James Madison University · USThe Ohio State University Wexner Medical Center · USMansfield University · USUniversity of Pennsylvania · US

Funding

Camille and Henry Dreyfus Foundation TH-18-019National Science Foundation MCB-1607024National Science Foundation MCB-2024182
6 · The paper itself

Abstract

Desmoplakin (DSP) is a large (~260 kDa) protein found in the desmosome, a subcellular complex that links the cytoskeleton of one cell to its neighbor. A mutation 'hot-spot' within the NH

Indexed as

arrhythmogenic cardiomyopathycalpaindesmoplakinmolecular dynamics

Identifiers

PMID34065787
PMCPMC8151963
OpenAlexW3161304853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.