ReviewMolecules (Basel, Switzerland)2021
Recent Research Progress in Taxol Biosynthetic Pathway and Acylation Reactions Mediated by
Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Completing the acylation landscape in plants: GDSL enzymes join the BAHD and SCPL acyltransferase families.Journal of experimental botany · 2026Review
- Toward Sustainable Paclitaxel Bioproduction: Plant Biology, Biosynthesis and Platform Engineering.Plants (Basel, Switzerland) · 2026Review
- Tobacco rattle virus triggers local defense and systemically coordinates taxoid biosynthesis in Taxus baccata revealed by integrated metabolic analysis.Scientific reports · 2026Article
- Phased high-quality genome of the gymnosperm Himalayan Yew assists in paclitaxel pathway exploration.GigaScience · 2025Article
- Paclitaxel production from endophytic3 Biotech · 2024Article
- Engineering cyanobacteria as a new platform for producing taxol precursors directly from carbon dioxide.Biotechnology for biofuels and bioproducts · 2024Article
- Genome-Wide Identification and Expression Pattern Analysis of BAHD Acyltransferase Family inInternational journal of molecular sciences · 2024Article
- Enhancement of paclitaxel production by Neopestalotiopsis vitis via optimization of growth conditions.PloS one · 2024Article
- Research Advances in Clinical Applications, Anticancer Mechanism, Total Chemical Synthesis, Semi-Synthesis and Biosynthesis of Paclitaxel.Molecules (Basel, Switzerland) · 2023Review
- Differential RNA-Seq Analysis Predicts Genes Related to Terpene Tailoring inPlants (Basel, Switzerland) · 2023Article
- Biosynthesis and the Transcriptional Regulation of Terpenoids in Tea Plants (International journal of molecular sciences · 2023Review
- Comparative Genome-Wide Analysis of TwoPlants (Basel, Switzerland) · 2023Article
- Family characteristics, phylogenetic reconstruction, and potential applications of the plant BAHD acyltransferase family.Frontiers in plant science · 2023Review
- New Trends and Future Opportunities in the Enzymatic Formation of C-C, C-N, and C-O bonds.Chembiochem : a European journal of chemical biology · 2022Review
- Transcription level differences inFrontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Taxol is one of the most effective anticancer drugs in the world that is widely used in the treatments of breast, lung and ovarian cancer. The elucidation of the taxol biosynthetic pathway is the key to solve the problem of taxol supply. So far, the taxol biosynthetic pathway has been reported to require an estimated 20 steps of enzymatic reactions, and sixteen enzymes involved in the taxol pathway have been well characterized, including a novel taxane-10β-hydroxylase (T10βOH) and a newly putative β-phenylalanyl-CoA ligase (PCL). Moreover, the source and formation of the taxane core and the details of the downstream synthetic pathway have been basically depicted, while the modification of the core taxane skeleton has not been fully reported, mainly concerning the developments from diol intermediates to 2-debenzoyltaxane. The acylation reaction mediated by specialized
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.