ArticleDiagnostics (Basel, Switzerland)2021
Sex-Related Differences in Cerebrospinal Fluid Plasma-Derived Proteins of Neurological Patients.
Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Surface-enhanced Raman scattering spectroscopy of human cerebrospinal fluid: protocol selection and biomolecular interpretation.Analytical and bioanalytical chemistry · 2026Article
- Effects of Biological Sex and Age on Cerebrospinal Fluid Markers-A Retrospective Observational Study.Annals of clinical and translational neurology · 2026Observational
- Kappa Free Light Chains in Multiple Sclerosis as a Marker of Intrathecal Humoral Response: A Sex-Disaggregated Study.Diagnostics (Basel, Switzerland) · 2024Article
- Intensity of Intrathecal Total IgG Synthesis in Multiple Sclerosis Correlates with the Degree of Pleocytosis, Diversity of Intrathecal Antiviral Antibody Specificities, and Female Sex.Antibodies (Basel, Switzerland) · 2024Article
- Breaking Barriers: Unveiling Sex-Related Differences in Cerebrospinal Fluid Analysis-A Narrative Review.Biology · 2024Review
- Sex Differences in Albumin Quotient and Cerebrospinal Fluid Total Protein Content Do Not Depend on Anthropometric Factors.Journal of personalized medicine · 2024Article
- Sex Differences under Vitamin D Supplementation in an Animal Model of Progressive Multiple Sclerosis.Nutrients · 2024Article
- The Sexual Dimorphism in Cerebrospinal Fluid Protein Content Does Not Affect Intrathecal IgG Synthesis in Multiple Sclerosis.Journal of personalized medicine · 2022Article
- Blood biomarkers for Alzheimer's disease: Reliable change and impacts of renal and blood-brain barrier function.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsCerebrospinal fluid (CSF) protein content presents a sexual dimorphism in humans. We investigated sex-related differences in CSF IgG levels and in the quantification of intrathecal IgG synthesis (IIS).
methodsCSF, serum albumin and IgG were measured in 1519 neurological patients and both linear and hyperbolic formulas were used for the quantification of IIS. CSF-restricted oligoclonal IgG bands (OCBs) were used as "gold standard".
resultsThe linear IgG Index showed a weak agreement with OCBs in males and females (k = 0.559, k = 0.587, respectively), while the hyperbolic Reiber's formulas had a moderate agreement with OCBs in females (k = 0.635) and a weak agreement in males (k = 0.565). Higher CSF albumin and IgG levels were found in men than in women in the whole population and in subjects without IIS after adjusting for age and for serum concentrations of albumin and IgG, respectively (Quade statistics,
conclusionsIn neurological patients, men have higher levels of CSF serum-derived proteins, such as albumin and IgG.
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