Evidence map›Paper›PMID 34065672›Full record

ArticleGenes2021

Molecular Pathways Associated with Kallikrein 6 Overexpression in Colorectal Cancer.

Ritu Pandey, Muhan Zhou, Yuliang Chen, Dalila Darmoul, Conner C Kisiel, Valentine N Nfonsam, Natalia A Ignatenko

Open access · goldAbstract read
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Ritu PandeyDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ 85721, USA.
Muhan ZhouBioinformatics Shared Resource, University of Arizona Cancer Center, Tucson, AZ 85724, USA.
Yuliang ChenBioinformatics Shared Resource, University of Arizona Cancer Center, Tucson, AZ 85724, USA.
Dalila DarmoulInstitut National de la Santé et de la Recherche Médicale (INSERM), Université de Paris, Lariboisière Hospital, 75010 Paris, France.ORCID 0000-0002-1206-0655
Conner C KisielUniversity of Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA.
Valentine N NfonsamDepartment of Surgery, Section of Surgical Oncology, University of Arizona, Tucson, AZ 85724, USA.
Natalia A IgnatenkoDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ 85721, USA.ORCID 0000-0002-8096-1340
University of Arizona · USInserm · FR

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Teri L Bankhead · 1985 to 2026
$110.2M
Role of Kallikrein 6 expression and secretion in colon cancerR01CA157595 · NCI · UNIVERSITY OF ARIZONA · PI IGNATENKO, NATALIA A · 2012 to 2016
$1.7M
NCI NIH HHS P30 CA023074NCI NIH HHS R01 CA157595
6 · The paper itself

Abstract

Colorectal cancer (CRC) remains one of the leading causes of cancer-related death worldwide. The high mortality of CRC is related to its ability to metastasize to distant organs. The kallikrein-related peptidase Kallikrein 6 (KLK6) is overexpressed in CRC and contributes to cancer cell invasion and metastasis. The goal of this study was to identify KLK6-associated markers for the CRC prognosis and treatment. Tumor Samples from the CRC patients with significantly elevated

Indexed as

Gene Regulatory NetworksAdenomatous Polyposis Coli ProteinCA-125 AntigenColorectal NeoplasmsConnectinExtracellular Matrix ProteinsFemaleGene Expression Regulation, NeoplasticHumansKallikreinsMaleMembrane ProteinsProto-Oncogene Proteins p21(ras)Signal TransductionTranscriptomeTumor Cells, CulturedAdenomatous Polyposis Coli ProteinAPC protein, humanCA-125 AntigenConnectinExtracellular Matrix ProteinsKallikreinsKLK6 protein, humanKRAS protein, humanMembrane ProteinsMUC16 protein, humanProto-Oncogene Proteins p21(ras)TTN protein, humancolorectal cancergene set enrichment analysiskallikrein 6K-RAS-oncogeneorganoid cultureregulatory pathwaysTCGA

Identifiers

PMID34065672
PMCPMC8157155
OpenAlexW3162570464

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.