Evidence map›Paper›PMID 34065634›Full record

ArticleViruses2021

Amino Acid Substitutions in NS5 Contribute Differentially to Tembusu Virus Attenuation in Ducklings and Cell Cultures.

Xue Sun, Mengxu Sun, Lijiao Zhang, Ziding Yu, Jinxin Li, Wanying Xie, Jingliang Su

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Comparative analysis of duck Tembusu virus Cluster 1 and Cluster 2.1 inCurrent research in parasitology & vector-borne diseases · 2025
    Article
  3. Article
  4. Persistence of Tembusu Virus inPathogens (Basel, Switzerland) · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xue SunKey Laboratory of Animal Epidemiology and Zoonosis, The Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Mengxu SunKey Laboratory of Animal Epidemiology and Zoonosis, The Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Lijiao ZhangInstitute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China.
Ziding YuKey Laboratory of Animal Epidemiology and Zoonosis, The Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Jinxin LiKey Laboratory of Animal Epidemiology and Zoonosis, The Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Wanying XieKey Laboratory of Animal Epidemiology and Zoonosis, The Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Jingliang SuKey Laboratory of Animal Epidemiology and Zoonosis, The Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tembusu virus (TMUV), a highly infectious pathogenic flavivirus, causes severe egg-drop and encephalitis in domestic waterfowl, while the determinants responsible for viral pathogenicity are largely unknown. In our previous studies, virulent strain JXSP

Indexed as

Amino Acid SubstitutionMutationVirus ReplicationAnimalsCell Culture TechniquesCell LineDucksFlavivirusFlavivirus InfectionsMutagenesis, Site-DirectedPoultry DiseasesProtein ConformationRNA, ViralStructure-Activity RelationshipViral Nonstructural ProteinsNS5 protein, flavivirusRNA, ViralViral Nonstructural Proteinsattenuationchimeric virusesRNA-dependent RNA polymeraseTembusu virusviral replication

Identifiers

PMID34065634
PMCPMC8156267

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.