ArticleJournal of clinical medicine2021
Ras, TrkB, and ShcA Protein Expression Patterns in Pediatric Brain Tumors.
Monika Prill, Agnieszka Karkucinska-Wieckowska, Magdalena Lebiedzinska-Arciszewska, Giampaolo Morciano, Agata Charzynska, Michal Dabrowski, Maciej Pronicki, Paolo Pinton, Wieslawa Grajkowska, Mariusz R Wieckowski
Open access · goldAbstract read
In one paragraphArticle in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors at 3 institutions in 2 countries.
Monika PrillLaboratory of Mitochondrial Biology and Metabolism, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.
Agnieszka Karkucinska-WieckowskaDepartment of Pathology, The Children's Memorial Health Institute, 04-730 Warsaw, Poland.ORCID 0000-0003-4936-1571 Magdalena Lebiedzinska-ArciszewskaLaboratory of Mitochondrial Biology and Metabolism, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.ORCID 0000-0002-2725-5551 Giampaolo MorcianoDepartment of Medical Sciences, Section of Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy.
Agata CharzynskaLaboratory of Bioinformatics, Nencki Institute of Experimental Biology, 02-093 Warsaw, Poland.
Michal DabrowskiLaboratory of Bioinformatics, Nencki Institute of Experimental Biology, 02-093 Warsaw, Poland.ORCID 0000-0002-5335-158X Maciej PronickiDepartment of Pathology, The Children's Memorial Health Institute, 04-730 Warsaw, Poland.
Paolo PintonDepartment of Medical Sciences, Section of Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0001-7108-6508 Wieslawa GrajkowskaDepartment of Pathology, The Children's Memorial Health Institute, 04-730 Warsaw, Poland.
Mariusz R WieckowskiLaboratory of Mitochondrial Biology and Metabolism, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.ORCID 0000-0003-0789-4521 Instytut Biologii Doświadczalnej im. Marcelego Nenckiego · PLChildren's Memorial Health Institute · PLUniversity of Ferrara · IT
Funding
Associazione Italiana per la Ricerca sul Cancro IG-23670Fondazione Telethon GGP11139BInternal Project of The Children's Memorial Health Institute G8/2020Internal Project of The Children's Memorial Health Institute S141/2014Narodowe Centrum Nauki UMO-2016/21/N/NZ1/00278Progetti di Rilevante Interesse Nazionale PRIN, 2017 E5L5P3Università degli Studi di Ferrara local funds
6 · The paper itselfAbstract
Numerous papers have reported altered expression patterns of Ras and/or ShcA proteins in different types of cancers. Their level can be potentially associated with oncogenic processes. We analyzed samples of pediatric brain tumors reflecting different groups such as choroid plexus tumors, diffuse astrocytic and oligodendroglial tumors, embryonal tumors, ependymal tumors, and other astrocytic tumors as well as tumor malignancy grade, in order to characterize the expression profile of Ras, TrkB, and three isoforms of ShcA, namely, p66Shc, p52Shc, and p46Shc proteins. The main aim of our study was to evaluate the potential correlation between the type of pediatric brain tumors, tumor malignancy grade, and the expression patterns of the investigated proteins.
Indexed as
malignancy gradepediatric brain tumorsRasShcATrkB
Identifiers
PMID34065573
PMCPMC8160917
OpenAlexW3165726006
What OpenQuestion holds
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LicenceCC BY
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