Evidence map›Paper›PMID 34065541›Full record

ReviewToxins2021

The Role of Ultrasound for the Personalized Botulinum Toxin Treatment of Cervical Dystonia.

Urban M Fietzek, Devavrat Nene, Axel Schramm, Silke Appel-Cresswell, Zuzana Košutzká, Uwe Walter, Jörg Wissel, Steffen Berweck, Sylvain Chouinard, Tobias Bäumer

Open access · goldAbstract readReview
In one paragraph

Review in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. The Role of Ultrasound in the Evaluation of Tardive Dyskinesia: A Case Series.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025
    Article
  11. Article
  12. Article
  13. Observational
  14. Review
  15. Article
  16. Hypertrophy of the Spinalis Cervicis Muscle in Cervical Dystonia.Tremor and other hyperkinetic movements (New York, N.Y.) · 2023
    Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 3 countries.

Urban M FietzekDepartment of Neurology, Ludwig-Maximilians-University, 81377 Munich, Germany.ORCID 0000-0002-4323-9930
Devavrat NeneDjavad Mowafaghian Centre for Brain Health, Division of Neurology, University of British Columbia Vancouver, Vancouver, BC V6T 1Z3, Canada.ORCID 0000-0002-3707-0067
Axel SchrammNeuroPraxis Fürth, 90762 Fürth, Germany.
Silke Appel-CresswellDjavad Mowafaghian Centre for Brain Health, Division of Neurology, University of British Columbia Vancouver, Vancouver, BC V6T 1Z3, Canada.
Zuzana Košutzká2nd Department of Neurology, Comenius University, 83305 Bratislava, Slovakia.
Uwe WalterDepartment of Neurology, University of Rostock, 18147 Rostock, Germany.ORCID 0000-0002-6280-785X
Jörg WisselNeurorehabilitation, Vivantes Klinikum Spandau, 13585 Berlin, Germany.
Steffen BerweckDepartment of Paediatric Neurology, Ludwig-Maximilians-University, 80337 Munich, Germany.
Sylvain ChouinardCentre hospitalier de l'Université de Montréal, Montréal, QC H2X 3E4, Canada.
Tobias BäumerInstitute of Systems Motor Science, University of Lübeck, 23562 Lübeck, Germany.
University of British Columbia · CACentre Hospitalier de l’Université de Montréal · CAComenius University Bratislava · SKKlinikum Fürth · DESchön Klinik München Schwabing · DESchön Klinik Vogtareuth · DEUniversity of Lübeck · DEUniversity of Rostock · DEVivantes Klinikum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The visualization of the human body has frequently been groundbreaking in medicine. In the last few years, the use of ultrasound (US) imaging has become a well-established procedure for botulinum toxin therapy in people with cervical dystonia (CD). It is now undisputed among experts that some of the most relevant muscles in this indication can be safely injected under visual US guidance. This review will explore the method from basic technical considerations, current evidence to conceptual developments of the phenomenology of cervical dystonia. We will review the implications of introducing US to our understanding of muscle function and anatomy of common cervical dystonic patterns. We suggest a flow chart for the use of US to achieve a personalized treatment of people with CD. Thus, we hope to contribute a resource that is useful in clinical practice and that stimulates the ongoing development of this valuable technique.

Indexed as

Botulinum ToxinsHumansNeuromuscular AgentsPrecision MedicineTorticollisUltrasonography, InterventionalBotulinum ToxinsNeuromuscular Agentsbotulinum toxincervical dystoniaultrasound

Identifiers

PMID34065541
PMCPMC8161276
OpenAlexW3165011716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.