Evidence map›Paper›PMID 34065502›Full record

ArticleViruses2021

Circovirus in Blood of a Febrile Horse with Hepatitis.

Alvin Hui, Eda Altan, Nathan Slovis, Caitlin Fletcher, Xutao Deng, Eric Delwart

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Alvin HuiVitalant Research Institute, San Francisco, CA 94118, USA.ORCID 0000-0001-6027-7958
Eda AltanVitalant Research Institute, San Francisco, CA 94118, USA.ORCID 0000-0001-7903-6986
Nathan SlovisHagyard Equine Medical Institute, 4250 Iron Works Pike, Lexington, KY 40361, USA.
Caitlin FletcherHagyard Equine Medical Institute, 4250 Iron Works Pike, Lexington, KY 40361, USA.
Xutao DengVitalant Research Institute, San Francisco, CA 94118, USA.
Eric DelwartVitalant Research Institute, San Francisco, CA 94118, USA.ORCID 0000-0002-6296-4484
University of California, San Francisco · USHagyard Equine Medical Institute · USPacific Research Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circoviruses infect vertebrates where they can result in a wide range of disease signs or in asymptomatic infections. Using viral metagenomics we analyzed a pool of five sera from four healthy and one sick horse. Sequences from parvovirus-H, equus anellovirus, and distantly related to mammalian circoviruses were recognized. PCR identified the circovirus reads as originating from a pregnant mare with fever and hepatitis. That horse's serum was also positive by real time PCR for equine parvovirus H and negative for the flavivirus equine hepacivirus. The complete circular genome of equine circovirus 1 strain Charaf (EqCV1-Charaf) was completed using PCR and Sanger sequencing. EqCV1 replicase showed 73-74% identity to those of their closest relatives, pig circoviruses 1/2, and elk circovirus. The closest capsid proteins were from the same ungulate circoviruses with 62-63% identity. The overall nucleotide identity of 72% to its closest relative indicates that EqCV1 is a new species in the

Indexed as

CircovirusAnimalsCircoviridae InfectionsGenome, ViralGenomicsHepatitis, Viral, AnimalHorse DiseasesHorsesPhylogenyViremiaCircoviridaeEquues caballushepatitisviral metagenomics

Identifiers

PMID34065502
PMCPMC8161410
OpenAlexW3162483989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.