Evidence map›Paper›PMID 34065497›Full record

ArticleNanomaterials (Basel, Switzerland)2021

Hyaluronic Acid-Based Nanocapsules as Efficient Delivery Systems of Garlic Oil Active Components with Anticancer Activity.

Małgorzata Janik-Hazuka, Kamil Kamiński, Marta Kaczor-Kamińska, Joanna Szafraniec-Szczęsny, Aleksandra Kmak, Hassan Kassassir, Cezary Watała, Maria Wróbel, Szczepan Zapotoczny

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Małgorzata Janik-HazukaJagiellonian University, Faculty of Chemistry, Gronostajowa 2, 30-387 Krakow, Poland.ORCID 0000-0002-2455-5030
Kamil KamińskiJagiellonian University, Faculty of Chemistry, Gronostajowa 2, 30-387 Krakow, Poland.ORCID 0000-0002-7421-6758
Marta Kaczor-KamińskaJagiellonian University Medical College, Faculty of Medicine, Chair of Medical Biochemistry, Kopernika 7, 31-034 Krakow, Poland.ORCID 0000-0002-2592-7676
Joanna Szafraniec-SzczęsnyJagiellonian University Medical College, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, Medyczna 9, 30-688 Krakow, Poland.ORCID 0000-0002-7163-1657
Aleksandra KmakJagiellonian University, Faculty of Chemistry, Gronostajowa 2, 30-387 Krakow, Poland.
Hassan KassassirMedical University of Lodz, Department of Haemostasis and Haemostatic Disorders, Chair of Biomedical Sciences, Mazowiecka 6/8, 92-215 Lodz, Poland.
Cezary WatałaMedical University of Lodz, Department of Haemostasis and Haemostatic Disorders, Chair of Biomedical Sciences, Mazowiecka 6/8, 92-215 Lodz, Poland.
Maria WróbelJagiellonian University Medical College, Faculty of Medicine, Chair of Medical Biochemistry, Kopernika 7, 31-034 Krakow, Poland.
Szczepan ZapotocznyJagiellonian University, Faculty of Chemistry, Gronostajowa 2, 30-387 Krakow, Poland.ORCID 0000-0001-6662-7621
Jagiellonian University · PLMedical University of Lodz · PL

Funding

Ministerstwo Nauki i Szkolnictwa Wyższego DI2015 015445
6 · The paper itself

Abstract

Diallyl disulfide (DADS) and diallyl trisulfide (DATS) are garlic oil compounds exhibiting beneficial healthy properties including anticancer action. However, these compounds are sparingly water-soluble with a limited stability that may imply damage to blood vessels or cells after administration. Thus, their encapsulation in the oil-core nanocapsules based on a derivative of hyaluronic acid was investigated here as a way of protecting against oxidation and undesired interactions with blood and digestive track components. The nuclear magnetic resonance (

Indexed as

diallyl disulfidediallyl trisulfidedrug deliveryencapsulationgarlic oilglutathionehyaluronic acidoil-core nanocapsulessulfane sulfursulfurtransferases

Identifiers

PMID34065497
PMCPMC8160828
OpenAlexW3163912228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.