ArticleDiagnostics (Basel, Switzerland)2021
Effects of Sex and Age on Fat Fraction, Diffusion-Weighted Image Signal Intensity and Apparent Diffusion Coefficient in the Bone Marrow of Asymptomatic Individuals: A Cross-Sectional Whole-Body MRI Study.
Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Predictive value of DWI signal and IVIM of pelvic bone marrow for hematological toxicity in rectal cancer patients undergoing concurrent chemoradiotherapy.Discover oncology · 2025Article
- Impact of fat content on lumbar spine DWI performance: A sex-based comparative study.European journal of radiology open · 2024Article
- Understanding ADC variation by fat content effect using a dual-function MRI phantom.European radiology experimental · 2024Article
- The quantitative parameters derived from IDEAL-IQ in the lumbar vertebrae of healthy children: a pilot study of bone development.Quantitative imaging in medicine and surgery · 2024Article
- A framework of biomarkers for skeletal aging: a consensus statement by the Aging Biomarker Consortium.Life medicine · 2023Article
- Advances in Bone Marrow Imaging: Strengths and Limitations from a Clinical Perspective.Seminars in musculoskeletal radiology · 2023Article
- Diffusion-Weighted MRI Monitoring of Embolic Brain Stroke for COVID-19 Patients.Advanced biomedical research · 2023Article
- Prediction of mobilized hematopoietic stem cell yield in patients with multiple myeloma: Usefulness of whole-body MRI-derived indices.PloS one · 2023Article
- Dual-Energy CT, Virtual Non-Calcium Bone Marrow Imaging of the Spine: An AI-Assisted, Volumetric Evaluation of a Reference Cohort with 500 CT Scans.Diagnostics (Basel, Switzerland) · 2022Article
- Study of bone marrow microstructure in healthy young adults using intravoxel incoherent motion diffusion-weighted MRI.Frontiers in endocrinology · 2022Article
- Whole-body magnetic resonance imaging (WB-MRI) for cancer screening: recommendations for use.La Radiologia medica · 2021Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
We aimed to describe the relationships between the relative fat fraction (%FF), muscle-normalized diffusion-weighted (DW) image signal intensity and water apparent diffusion coefficient (ADC), sex and age for normal bone marrow, in the normal population. Our retrospective cohort consisted of 100 asymptomatic individuals, equally divided by sex and 10-year age groups, who underwent whole-body MRI at 1.5 T for early cancer detection. Semi-automated segmentation of global bone marrow volume was performed using the DW images and the resulting segmentation masks were projected onto the ADC and %FF maps for extraction of parameter values. Differences in the parameter values between sexes at age ranges were assessed using the Mann-Whitney and Kruskal-Wallis tests. The Spearman correlation coefficient r was used to assess the relationship of each imaging parameter with age, and of %FF with ADC and normalized DW signal intensity values. The average %FF of normal bone marrow was 65.6 ± 7.2%, while nSI
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