ArticleCancers2021
Evaluation of the Ginsburg Scheme: Where Is Significant Prostate Cancer Missed?
Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The learning curve for robotic-assisted transperineal MRI/US fusion-guided prostate biopsy.Scientific reports · 2024Trial
- PRE-POET: a qualitative interview-based study to explore patient-relevant factors in the context of prostate biopsy.BMC urology · 2025Article
- Article
- Schema and cancer detection rates for transperineal prostate biopsy templates: a review.Therapeutic advances in urologyReview
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11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundSystematic biopsy (SB) according to the Ginsburg scheme (GBS) is widely used to complement MRI-targeted biopsy (MR-TB) for optimizing the diagnosis of clinically significant prostate cancer (sPCa). Knowledge of the GBS's blind sectors where sPCa is missed is crucial to improve biopsy strategies.
methodsWe analyzed cancer detection rates in 1084 patients that underwent MR-TB and SB. Cancerous lesions that were missed or underestimated by GBS were re-localized onto a prostate map encompassing Ginsburg sectors and blind-sectors (anterior, central, basodorsal and basoventral). Logistic regression analysis (LRA) and prostatic configuration analysis were applied to identify predictors for missing sPCa with the GBS.
resultsGBS missed sPCa in 39 patients (39/1084, 3.6%). In 27 cases (27/39, 69.2%), sPCa was missed within a blind sector, with 17/39 lesions localized in the anterior region (43.6%). Neither LRA nor prostatic configuration analysis identified predictors for missing sPCa with the GBS.
conclusionsThis is the first study to analyze the distribution of sPCa missed by the GBS. GBS misses sPCa in few men only, with the majority localized in the anterior region. Adding blind sectors to GBS defined a new sector map of the prostate suited for reporting histopathological biopsy results.
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