Evidence map›Paper›PMID 34065234›Full record

ArticleViruses2021

Hanieh Ghassabian, Federico Falchi, Martina Timmoneri, Beatrice Mercorelli, Arianna Loregian, Giorgio Palù, Gualtiero Alvisi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hanieh GhassabianDepartment of Molecular Medicine, University of Padova, 35121 Padova, Italy.
Federico FalchiMolecular Horizon, 06084 Bettona, Italy.ORCID 0000-0001-7385-649X
Martina TimmoneriDepartment of Molecular Medicine, University of Padova, 35121 Padova, Italy.
Beatrice MercorelliDepartment of Molecular Medicine, University of Padova, 35121 Padova, Italy.ORCID 0000-0003-0654-8045
Arianna LoregianDepartment of Molecular Medicine, University of Padova, 35121 Padova, Italy.ORCID 0000-0002-8900-861X
Giorgio PalùDepartment of Molecular Medicine, University of Padova, 35121 Padova, Italy.
Gualtiero AlvisiDepartment of Molecular Medicine, University of Padova, 35121 Padova, Italy.ORCID 0000-0002-8177-3616
University of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) is a leading cause of severe diseases in immunocompromised individuals, including AIDS patients and transplant recipients, and in congenitally infected newborns. The utility of available drugs is limited by poor bioavailability, toxicity, and emergence of resistant strains. Therefore, it is crucial to identify new targets for therapeutic intervention. Among the latter, viral protein-protein interactions are becoming increasingly attractive. Since dimerization of HCMV DNA polymerase processivity factor ppUL44 plays an essential role in the viral life cycle, being required for oriLyt-dependent DNA replication, it can be considered a potential therapeutic target. We therefore performed an

Indexed as

Antiviral AgentsBinding SitesCell LineCytomegalovirusDose-Response Relationship, DrugDrug DiscoveryGene Expression Regulation, ViralHumansModels, MolecularMolecular ConformationMolecular StructureProtein BindingProtein MultimerizationStructure-Activity RelationshipViral ProteinsVirus ReplicationAntiviral AgentsViral ProteinsantiviralsHCMVPAPppUL44protein-protein interactionspUL54screeningsmall molecules

Identifiers

PMID34065234
PMCPMC8160850
OpenAlexW3108448841

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.