Evidence map›Paper›PMID 34065149›Full record

ArticleInternational journal of molecular sciences2021

Trichodermin Induces G0/G1 Cell Cycle Arrest by Inhibiting c-Myc in Ovarian Cancer Cells and Tumor Xenograft-Bearing Mice.

Ying Gao, Sarah L Miles, Piyali Dasgupta, Gary O Rankin, Stephen Cutler, Yi Charlie Chen

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Inhibitory Effect and Mechanism ofJournal of fungi (Basel, Switzerland) · 2022
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Ying GaoTea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 310008, China.ORCID 0000-0003-0696-7880
Sarah L MilesDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA.ORCID 0000-0002-7997-2309
Piyali DasguptaDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA.
Gary O RankinDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA.ORCID 0000-0002-5385-3512
Stephen CutlerCollege of Pharmacy, University of South Carolina, CLS Columbia, Columbia, SC 29208, USA.
Yi Charlie ChenCollege of Health, Science, Technology and Mathematics, Alderson Broaddus University, Philippi, WV 26416, USA.ORCID 0000-0001-6865-9512
Marshall University · USAlderson Broaddus University · USChinese Academy of Agricultural Sciences · CNUniversity of South Carolina · US

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Sally Lynn Hodder · 2012 to 2026
$81.0M
WV INBRE: The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast CancerP20GM103434 · NIGMS · MARSHALL UNIVERSITY · PI GARY O RANKIN · 2012 to 2026
$61.1M
Capsaicin and Small cell Lung Cancer TherapyR15CA161491 · NCI · MARSHALL UNIVERSITY · PI DASGUPTA, PIYALI · 2012 to 2021
$1.3M
NCI NIH HHS R15 CA161491NIGMS NIH HHS U54 GM104942NIH HHS P20GM103434
6 · The paper itself

Abstract

Ovarian cancer is a fatal gynecological cancer because of a lack of early diagnosis, which often relapses as chemoresistant. Trichodermin, a trichothecene first isolated from

Indexed as

Genes, mycAnimalsBiomarkers, TumorCell CycleCell Line, TumorCell ProliferationCell SurvivalCyclin-Dependent KinasesDisease Models, AnimalFemaleG1 Phase Cell Cycle CheckpointsGene Expression Regulation, NeoplasticHumansMiceOvarian NeoplasmsTrichoderminBiomarkers, TumorCyclin-Dependent KinasesTrichoderminA2780/CP70 cellsCdc25Acell cycle arrestc-MycOVCAR-3 cellstrichodermin

Identifiers

PMID34065149
PMCPMC8126000
OpenAlexW3160469871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.