ReviewAntibiotics (Basel, Switzerland)2021
Honey as an Ecological Reservoir of Antibacterial Compounds Produced by Antagonistic Microbial Interactions in Plant Nectars, Honey and Honey Bee.
Review in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Article
- Comparison of Inoculation Routes for Honeybee Gut Microbiota Assembly Under Laboratory Conditions.Microorganisms · 2026Article
- Honey-biosynthesized silver nanoparticles against vancomycin-resistant enterococci: integrated antibacterial, antibiofilm, mechanistic and preliminary safety evaluation.Scientific reports · 2026Article
- Antimicrobial and Antibiofilm Activity of Acacia and Polyfloral Honey: Physicochemical Characterization and Correlation with Antibacterial Efficacy.Foods (Basel, Switzerland) · 2026Article
- In Vivo and In Vitro Evaluation of Probiotic and Postbiotic Strategies Against Foulbrood in Honeybees.Probiotics and antimicrobial proteins · 2026Article
- Antimicrobial Resistance: The Answers.British journal of biomedical science · 2026Review
- Hive-associated bacteria improve honeybee survival duringbioRxiv : the preprint server for biology · 2025Article
- Characterization of Honey Microbiome Using MALDI-TOF Mass Spectrometry and Physicochemical Study.Molecules (Basel, Switzerland) · 2025Review
- Physicochemical parameters, microbiological quality, and antibacterial activity of honey from the Bucovina region of Romania.Scientific reports · 2025Article
- Effectiveness of a Novel Liposomal Methylglyoxal-Tobramycin Formulation in Reducing Biofilm Formation and Bacterial Adhesion.Antibiotics (Basel, Switzerland) · 2024Article
- Bee products: An overview of sources, biological activities and advanced approaches used in apitherapy application.Biotechnology reports (Amsterdam, Netherlands) · 2024Review
- Honey microbiota, methods for determining the microbiological composition and the antimicrobial effect of honey - A review.Food chemistry: X · 2024Review
- Antimicrobial Activity of Honey and Propolis from Alba County, Romania.Antibiotics (Basel, Switzerland) · 2024Article
- Effects of Artificial Sugar Supplementation on the Composition and Nutritional Potency of Honey fromInsects · 2024Article
- Shotgun Metagenomics Reveals Minor Micro"International journal of molecular sciences · 2024Article
- In Silico Safety Assessment ofInternational journal of molecular sciences · 2024Article
- Manuka honey as a non-antibiotic alternative againstFrontiers in cellular and infection microbiology · 2024Review
- Antimicrobial Properties, Functional Characterisation and Application of Fructobacillus fructosus and Lactiplantibacillus plantarum Isolated from Artisanal Honey.Probiotics and antimicrobial proteins · 2023Article
- Whole-genome sequencing and antimicrobial potential of bacteria isolated from Polish honey.Applied microbiology and biotechnology · 2023Article
- Microbiological Quality of Polish Artisanal Varietal Honeys.Foods (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fundamental feature of "active honeys" is the presence and concentration of antibacterial compounds. Currently identified compounds and factors have been described in several review papers without broader interpretation or links to the processes for their formation. In this review, we indicate that the dynamic, antagonistic/competitive microbe-microbe and microbe-host interactions are the main source of antibacterial compounds in honey. The microbial colonization of nectar, bees and honey is at the center of these interactions that in consequence produce a range of defence molecules in each of these niches. The products of the microbial interference and exploitive competitions include antimicrobial peptides, antibiotics, surfactants, inhibitors of biofilm formation and quorum sensing. Their accumulation in honey by horizontal transfer might explain honey broad-spectrum, pleiotropic, antibacterial activity. We conclude that honey is an ecological reservoir of antibacterial compounds produced by antagonistic microbial interactions in plant nectars, honey and honey bee. Thus, refocusing research on secondary metabolites resulting from these microbial interactions might lead to discovery of new antibacterial compounds in honey that are target-specific, i.e., acting on specific cellular components or inhibiting the essential cellular function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.