Evidence map›Paper›PMID 34064954›Full record

ArticlePolymers2021

Antibacterial and Bonding Properties of Universal Adhesive Dental Polymers Doped with Pyrogallol.

Naji Kharouf, Ammar Eid, Louis Hardan, Rim Bourgi, Youri Arntz, Hamdi Jmal, Federico Foschi, Salvatore Sauro, Vincent Ball, Youssef Haikel and 1 more

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Evolution of Dental Resin Adhesives-A Comprehensive Review.Journal of functional biomaterials · 2025
    Review
  3. Article
  4. Article
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  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 6 countries.

Naji KharoufDepartment of Endodontics, Faculty of Dental Medicine, Strasbourg University, 67000 Strasbourg, France.ORCID 0000-0001-6768-138X
Ammar EidDepartment of Endodontics, Faculty of Dental Medicine, Damascus University, Damascus 0100, Syria.
Louis HardanDepartment of Restorative Dentistry, Saint-Joseph University, Beirut 11072180, Lebanon.ORCID 0000-0001-8577-2285
Rim BourgiDepartment of Restorative Dentistry, Saint-Joseph University, Beirut 11072180, Lebanon.ORCID 0000-0002-8003-2664
Youri ArntzDepartment of Endodontics, Faculty of Dental Medicine, Strasbourg University, 67000 Strasbourg, France.
Hamdi JmalICube Laboratory, UMR 7357 CNRS, Mechanics Department, University of Strasbourg, 67000 Strasbourg, France.ORCID 0000-0001-6480-1139
Federico FoschiDepartment of Endodontics, Faculty of Dentistry, Oral & Craniofacial Sciences, Floor 22 Tower Wing, Guy's Dental Hospital, London SE1 9RT, UK.ORCID 0000-0001-6901-0280
Salvatore SauroDepartment of Therapeutic Dentistry, I.M. Sechenov First Moscow State Medical University, 119146 Moscow, Russia.ORCID 0000-0002-2527-8776
Vincent BallDepartment of Endodontics, Faculty of Dental Medicine, Strasbourg University, 67000 Strasbourg, France.
Youssef HaikelDepartment of Endodontics, Faculty of Dental Medicine, Strasbourg University, 67000 Strasbourg, France.
Davide MancinoDepartment of Endodontics, Faculty of Dental Medicine, Strasbourg University, 67000 Strasbourg, France.
Inserm · FRSaint Joseph University · LBCentre National de la Recherche Scientifique · FRDamascus University · SYGuy's Hospital · GBSechenov University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the antibacterial activity, bond strength to dentin (SBS), and ultra-morphology of the polymer-dentin interface of experimental adhesive systems doped with pyrogallol (PY), which is a ubiquitous phenolic moiety that is present in flavonoids and polyphenols. A universal adhesive containing 4-META and 10-MDP was used in this study. PY behaves as an antioxidant and anti-cancerogenic agent and it was incorporated into the adhesive at different concentrations (0.5 and 1 wt.%). The antibacterial activity and SBS were analyzed and the results were statistically analyzed. The ultra-morphology of the polymer-dentin interface was assessed using scanning electron microscopy (SEM). At 24 h, a lower antibacterial activity was observed for the control adhesive compared to those with 0.5% and 1% PY. No difference was seen in SBS between the three groups at 24 h. After 6 months, the SBS of the 0.5% PY adhesive was significantly lower than the other tested adhesives. The specimens created with 1% PY adhesive presented a higher bond strength at six months compared with that found at 24 h. No morphological differences were found at the polymer-dentin interfaces of the tested adhesives. Pyrogallol may be incorporated into modern universal adhesive systems to preserve the polymer-dentin bonding interface and confer a certain degree of antibacterial activity.

Indexed as

antibacterial activitybond strengthpolymer–dentin interfacepyrogalloluniversal adhesive

Identifiers

PMID34064954
PMCPMC8151108
OpenAlexW3161057520

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.