ArticleInternational journal of molecular sciences2021
Conditional Loss of the Exocyst Component Exoc5 in Retinal Pigment Epithelium (RPE) Results in RPE Dysfunction, Photoreceptor Cell Degeneration, and Decreased Visual Function.
Bärbel Rohrer, Manas R Biswal, Elisabeth Obert, Yujing Dang, Yanhui Su, Xiaofeng Zuo, Ben Fogelgren, Altaf A Kondkar, Glenn P Lobo, Joshua H Lipschutz
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors at 5 institutions in 2 countries.
Bärbel RohrerDepartment of Ophthalmology, Medical University of South Carolina, Charleston, SC 29425, USA.
Manas R BiswalDepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0002-9685-2923
Elisabeth ObertDepartment of Ophthalmology, Medical University of South Carolina, Charleston, SC 29425, USA.
Yujing DangDepartment of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Yanhui SuDepartment of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Xiaofeng ZuoDepartment of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Ben FogelgrenDepartment of Anatomy, Biochemistry, and Physiology, University of Hawaii at Manoa, Honolulu, HI 96813, USA.
Altaf A KondkarDepartment of Ophthalmology, College of Medicine, King Saud University, Riyadh 11411, Saudi Arabia.ORCID 0000-0002-5516-6951
Glenn P LoboDepartment of Ophthalmology, Medical University of South Carolina, Charleston, SC 29425, USA.
Joshua H LipschutzDepartment of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Medical University of South Carolina · USKing Saud University · SAUniversity of Hawaiʻi at Mānoa · USUniversity of Minnesota · USUniversity of South Florida · US
Funding
Translational Pilot Project ProgramP30GM131944 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI WARD, WILLIAM S · 2019 to 2023
$5.9M
Alternative Pathway of Complement Activation in Age-Related Macular DegenerationR01EY019320 · NEI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ROHRER, BAERBEL · 2010 to 2014
$2.1M
The exocyst in ureter development and congenital obstructionsR01DK117308 · NIDDK · UNIVERSITY OF HAWAII AT MANOA · PI FOGELGREN, BENJAMIN C. · 2018 to 2020
$1.2M
Defining oxidative stress induced changes in RPE that control RPE and photoreceptor degenerationR00EY027013 · NEI · UNIVERSITY OF SOUTH FLORIDA · PI BISWAL, MANAS R · 2019 to 2021
$960k
The exocyst in kidney development and cyst formationK01DK087852 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI FOGELGREN, BENJAMIN C. · 2010 to 2014
$764k
Physiological Role of the Zebrafish Retinol Receptor rbpr2 in VisionR21EY025034 · NEI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LOBO, GLENN P · 2015 to 2016
$436k
Defining oxidative stress induced changes in RPE that control RPE and photoreceptor degenerationK99EY027013 · NEI · UNIVERSITY OF FLORIDA · PI BISWAL, MANAS R · 2016 to 2017
$258k
A novel genetic model for congenital obstructive nephropathyR03DK100738 · NIDDK · UNIVERSITY OF HAWAII AT MANOA · PI FOGELGREN, BENJAMIN C. · 2014 to 2015
$152k
BLR&D Research Career Scientist Award for Dr. Barbel RohrerIK6BX004858 · VA · RALPH H JOHNSON VA MEDICAL CENTER · PI Baerbel Rohrer · 2020 to 2026
–
Complement Factor H Haplotypes and Smoking in Age-Related Macular DegenerationI01RX000444 · VA · RALPH H JOHNSON VA MEDICAL CENTER · PI Baerbel Rohrer · 2011 to 2026
–
RPE Cell Bystander Effects Contribute to AMD PathologyI01BX003050 · VA · RALPH H JOHNSON VA MEDICAL CENTER · PI ROHRER, BAERBEL · 2016 to 2024
To characterize the mechanisms by which the highly conserved exocyst trafficking complex regulates eye physiology in zebrafish and mice, we focused on Exoc5 (also known as
Indexed as
Retinal DegenerationAnimalsMiceMice, Inbred C57BLMice, KnockoutPhotoreceptor CellsRetinal Pigment EpitheliumVesicular Transport ProteinsVision DisordersZebrafishEXOC5 protein, mouseVesicular Transport Proteinsexocyst complex component 5photoreceptorretinal pigmented epitheliumvisual function
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Conditional Loss of the Exocyst Component Exoc5 in Retinal Pigment Epithelium (RPE) Results in RPE Dysfunction, Photoreceptor Cell Degeneration, and Decreased Visual Function. · full record | OpenQuestion