Evidence map›Paper›PMID 34064877›Full record

ArticleJournal of clinical medicine2021

The Ratio of C-Reactive Protein to Albumin Is an Independent Predictor of Malignant Intraductal Papillary Mucinous Neoplasms of the Pancreas.

Simone Serafini, Alberto Friziero, Cosimo Sperti, Lorenzo Vallese, Andrea Grego, Alfredo Piangerelli, Amanda Belluzzi, Lucia Moletta

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Humoral Predictors of Malignancy in IPMN: A Review of the Literature.International journal of molecular sciences · 2021
    Review
  8. Recent Advances in Pancreatic Neoplasms.Journal of clinical medicine · 2021
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Simone SerafiniDepartment of Surgery, Oncology and Gastroenterology, 3rd Surgery Clinic, University of Padua, via Giustiniani 2, 35128 Padua, Italy.ORCID 0000-0003-1465-8439
Alberto FrizieroDepartment of Surgery, Oncology and Gastroenterology, 3rd Surgery Clinic, University of Padua, via Giustiniani 2, 35128 Padua, Italy.
Cosimo SpertiDepartment of Surgery, Oncology and Gastroenterology, 3rd Surgery Clinic, University of Padua, via Giustiniani 2, 35128 Padua, Italy.ORCID 0000-0002-7869-8715
Lorenzo ValleseDepartment of Surgery, SS. Giovanni and Paolo Hospital, Sestiere Castello 6777, 30122 Venice, Italy.
Andrea GregoDepartment of Surgery, Oncology and Gastroenterology, 3rd Surgery Clinic, University of Padua, via Giustiniani 2, 35128 Padua, Italy.ORCID 0000-0002-7217-3184
Alfredo PiangerelliDepartment of Surgery, Oncology and Gastroenterology, 3rd Surgery Clinic, University of Padua, via Giustiniani 2, 35128 Padua, Italy.
Amanda BelluzziDepartment of Surgery, Oncology and Gastroenterology, 3rd Surgery Clinic, University of Padua, via Giustiniani 2, 35128 Padua, Italy.
Lucia MolettaDepartment of Surgery, Oncology and Gastroenterology, 3rd Surgery Clinic, University of Padua, via Giustiniani 2, 35128 Padua, Italy.ORCID 0000-0003-4041-5721
University of Padua · ITOspedale San Paolo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is growing evidence to indicate that inflammatory reactions are involved in cancer progression. The aim of this study is to assess the significance of systemic inflammatory biomarkers, such as the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), the ratio of C-reactive protein to albumin ratio (CAR), the prognostic nutritional index (PNI) and the modified Glasgow prognostic score (mGps) in the diagnosis and prognosis of malignant intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. Data were obtained from a retrospective analysis of patients who underwent pancreatic resection for IPMNs from January 2005 to December 2015. Univariate and multivariate analyses were performed, considering preoperative inflammatory biomarkers, clinicopathological variables, and imaging features. Eighty-three patients with histologically proven IPMNs of the pancreas were included in the study, 37 cases of low-grade or intermediate dysplasia and 46 cases of high-grade dysplasia (HGD) or invasive carcinoma. Univariate analysis showed that obstructive jaundice (

Indexed as

biomarkerC-reactive protein to albumin ratioinflammationintraductal papillary mucinous neoplasmmodified Glasgow prognostic scoreneutrophyl lymphocite ratiopancreatic cancerplatelet-to-lymphocyte ratio

Identifiers

PMID34064877
PMCPMC8150937
OpenAlexW3161948140

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.