Evidence map›Paper›PMID 34064835›Full record

ReviewCells2021

Transient Receptor Potential Channel Ankyrin 1: A Unique Regulator of Vascular Function.

Michael G Alvarado, Pratish Thakore, Scott Earley

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
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  10. Cracking the Endothelial Calcium (CaInternational journal of molecular sciences · 2023
    Review
  11. Vasodilators mobilize SK3 channels in endothelial cells to produce arterial relaxation.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Article
  13. Article
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Michael G AlvaradoCenter for Molecular and Cellular Signaling in the Cardiovascular System, Department of Pharmacology, Reno School of Medicine, University of Nevada, Reno, NV 89557-0318, USA.
Pratish ThakoreCenter for Molecular and Cellular Signaling in the Cardiovascular System, Department of Pharmacology, Reno School of Medicine, University of Nevada, Reno, NV 89557-0318, USA.
Scott EarleyCenter for Molecular and Cellular Signaling in the Cardiovascular System, Department of Pharmacology, Reno School of Medicine, University of Nevada, Reno, NV 89557-0318, USA.ORCID 0000-0001-9560-2941
University of Nevada, Reno · US

Funding

Transgenic Animal Genotyping and Phenotyping CoreP20GM130459 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Nathan Grainger · 2019 to 2026
$20.3M
TRP channels as fundamental sensors of the cerebral microcirculationR35HL155008 · NHLBI · UNIVERSITY OF ROCHESTER · PI Scott Earley · 2021 to 2026
$5.5M
The Neural Mechanisms of HypertensionR01HL122770 · NHLBI · UNIVERSITY OF ROCHESTER · PI FENG EARLEY, YUMEI · 2015 to 2023
$4.2M
Role of ANO1 Channels and Its Regulation by PIP2 in EC-Coupling in Pulmonary Artery MyocytesR01HL146054 · NHLBI · UNIVERSITY OF NEVADA RENO · PI EARLEY, SCOTT, LEBLANC, NORMAND · 2019 to 2022
$2.0M
Development and validation of novel models for cerebral small vessel disease and vascular cognitive impairmentR61NS115132 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAUMEIL, MYRIAM MARIANNE, EARLEY, SCOTT · 2019 to 2020
$1.1M
NHLBI NIH HHS R01 HL122770NHLBI NIH HHS R01 HL146054NHLBI NIH HHS R35 HL155008NIGMS NIH HHS P20 GM130459NINDS NIH HHS R61 NS115132
6 · The paper itself

Abstract

TRPA1 (transient receptor potential ankyrin 1), the lone member of the mammalian ankyrin TRP subfamily, is a Ca

Indexed as

Gene Expression RegulationAldehydesAnimalsCalcitoninCalciumCalcium ChannelsCardiovascular SystemCrotalusEndothelial CellsHumansHypertensionInflammationIsothiocyanatesMolecular ConformationMustard PlantNerve Tissue Proteins4-hydroxy-2-nonenalAldehydesallyl isothiocyanateCalcitoninCalciumCalcium ChannelsIsothiocyanatesmustard oilNerve Tissue ProteinsPlant OilsTransient Receptor Potential ChannelsTRPA1 Cation ChannelTRPA1 protein, humanendothelial cellinflammationneurovascular couplingstrokeTRPA1

Identifiers

PMID34064835
PMCPMC8151290
OpenAlexW3163118966

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.