Evidence map›Paper›PMID 34064808›Full record

ArticleToxins2021

An Smp43-Derived Short-Chain α-Helical Peptide Displays a Unique Sequence and Possesses Antimicrobial Activity against Both Gram-Positive and Gram-Negative Bacteria.

Xudong Luo, Li Ding, Xiangdong Ye, Wen Zhu, Kaiyue Zhang, Fangyan Li, Huiwen Jiang, Zhiwen Zhao, Zongyun Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xudong LuoDepartment of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, College of Basic Medicine, Hubei University of Medicine, Shiyan 442000, China.ORCID 0000-0003-2265-3099
Li DingDepartment of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, College of Basic Medicine, Hubei University of Medicine, Shiyan 442000, China.
Xiangdong YeDepartment of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, College of Basic Medicine, Hubei University of Medicine, Shiyan 442000, China.
Wen ZhuDepartment of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, College of Basic Medicine, Hubei University of Medicine, Shiyan 442000, China.
Kaiyue ZhangDepartment of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, College of Basic Medicine, Hubei University of Medicine, Shiyan 442000, China.
Fangyan LiDepartment of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, College of Basic Medicine, Hubei University of Medicine, Shiyan 442000, China.
Huiwen JiangDepartment of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, College of Basic Medicine, Hubei University of Medicine, Shiyan 442000, China.
Zhiwen ZhaoDepartment of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, College of Basic Medicine, Hubei University of Medicine, Shiyan 442000, China.
Zongyun ChenDepartment of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, College of Basic Medicine, Hubei University of Medicine, Shiyan 442000, China.
Hubei University of Medicine · CN

Funding

National Natural Sciences Foundation of China 81773746National Natural Sciences Foundation of China 81973321Natural Science Foundation of Hubei Provincial Department of Education D20182103Natural Science Foundation of Hubei Provincial Department of Education Q20202102Natural Science Foundation of Hubei Provincial Department of Education Q20202103Principal Investigator Grant of Hubei University of Medicine HBMUPI201801School Natural Science Fund of Hubei University of Medicine 2017QDJZR14School Natural Science Fund of Hubei University of Medicine FDFR201906
6 · The paper itself

Abstract

Scorpion venoms are rich resources of antimicrobial peptides (AMPs). While the short-chain noncysteine-containing AMPs have attracted much attention as templates for drug development, the antimicrobial potential of long-chain noncysteine-containing AMPs has been largely overlooked. Here, by using the online HeliQuest server, we designed and analyzed a series of 14-residue fragments of Smp43, a 43-residue long-chain noncysteine-containing AMP identified from the venom of

Indexed as

AnimalsAnti-Bacterial AgentsCell MembraneGram-Negative BacteriaGram-Positive BacteriaPore Forming Cytotoxic ProteinsProtein Conformation, alpha-HelicalScorpionsScorpion VenomsAnti-Bacterial AgentsPore Forming Cytotoxic ProteinsScorpion Venomsantimicrobial resistanceHeliQuestnoncysteine-containing AMPsscorpion venomSmp43Smp43(1-14)

Identifiers

PMID34064808
PMCPMC8150835
OpenAlexW3162722629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.